The gradual reprogramming of haematopoietic precursors into the T-cell fate is characterized by at least two sequential developmental stages. Following Notch1-dependent T-cell lineage specification during which the first T-cell lineage genes are expressed and myeloid and dendritic cell potential is lost, T-cell specific transcription factors subsequently induce T-cell commitment by repressing residual natural killer (NK)-cell potential. How these processes are regulated in human is poorly understood, especially since efficient T-cell lineage commitment requires a reduction in Notch signalling activity following T-cell specification. Here, we show that GATA3, in contrast to TCF1, controls human T-cell lineage commitment through direct regula...
SummaryThe mechanisms underlying the silencing of alternative fate potentials in very early B cell p...
Precursor cell entry into the T-cell developmental pathway can be divided into two phases by the clo...
Notch signalling is a critical mediator of T cell development. However, while this signalling pathwa...
The gradual reprogramming of haematopoietic precursors into the T-cell fate is characterized by at l...
T-cell precursors remain developmentally plastic for multiple cell generations after entering the th...
The T-cell development program is specifically triggered by Notch-Delta signaling, but most transcri...
International audienceTranscription factors orchestrate T-lineage differentiation in the thymus. One...
SummaryNotch signaling plays multiple roles to direct diverse decisions regarding cell fate during T...
T-lymphocyte development branches off from other lymphoid developmental programs through its require...
GATA3 and Notch1 are essential for T cell development at the earliest stage, but their mutual roles ...
The adaptive immune response, including antigen-specific T cells, is crucial in resolving infections...
Multipotent blood progenitor cells enter the thymus and begin a protracted differentiation process i...
GATA-3 is essential for T cell development from the earliest stages. However, abundant GATA-3 can dr...
T lymphocytes comprise one arm of the adaptive immune system and are critical for immunity to neopla...
Transcription factors orchestrate T-lineage differentiation in the thymus. One critical checkpoint i...
SummaryThe mechanisms underlying the silencing of alternative fate potentials in very early B cell p...
Precursor cell entry into the T-cell developmental pathway can be divided into two phases by the clo...
Notch signalling is a critical mediator of T cell development. However, while this signalling pathwa...
The gradual reprogramming of haematopoietic precursors into the T-cell fate is characterized by at l...
T-cell precursors remain developmentally plastic for multiple cell generations after entering the th...
The T-cell development program is specifically triggered by Notch-Delta signaling, but most transcri...
International audienceTranscription factors orchestrate T-lineage differentiation in the thymus. One...
SummaryNotch signaling plays multiple roles to direct diverse decisions regarding cell fate during T...
T-lymphocyte development branches off from other lymphoid developmental programs through its require...
GATA3 and Notch1 are essential for T cell development at the earliest stage, but their mutual roles ...
The adaptive immune response, including antigen-specific T cells, is crucial in resolving infections...
Multipotent blood progenitor cells enter the thymus and begin a protracted differentiation process i...
GATA-3 is essential for T cell development from the earliest stages. However, abundant GATA-3 can dr...
T lymphocytes comprise one arm of the adaptive immune system and are critical for immunity to neopla...
Transcription factors orchestrate T-lineage differentiation in the thymus. One critical checkpoint i...
SummaryThe mechanisms underlying the silencing of alternative fate potentials in very early B cell p...
Precursor cell entry into the T-cell developmental pathway can be divided into two phases by the clo...
Notch signalling is a critical mediator of T cell development. However, while this signalling pathwa...