Strongylocentrotus purpuratus Otx (SpOtx) is required simultaneously in sea urchin development for the activation of endo16 in the vegetal plate and for the activation of spec2a in the aboral ectoderm. Because Otx binding sites alone do not appear to be responsible for the spatially restricted expression of spec2a, additional DNA elements were sought. We show here that consensus Otx binding sites fused to basal promoters are sufficient to activate CAT reporter gene expression in all cell types, although expression in endomesoderm progenitors is enhanced. On the other hand, three non-Otx elements derived from the spec2a enhancer are needed together with Otx sites for specifically aboral ectoderm expression. A DNA element termed Y/CBF, lying ...
AbstractWe demonstrate that interspecific sequence conservation can provide a systematic guide to th...
Embryonic development is coordinated by networks of evolutionary conserved regulatory genes encoding...
AbstractThe sea urchin (Hemicentrotus pulcherrimus) arylsulfatase (HpArs) gene, expressed specifical...
AbstractStrongylocentrotus purpuratus Otx (SpOtx) is required simultaneously in sea urchin developme...
To understand how a eukaryote achieves differential transcription of genes in precise spatial patter...
An important question in developmental biology is how embryonic cell types are derived from a fertil...
AbstractOrthodenticle-related (Otx) proteins are a highly conserved class of homeobox-containing tra...
The Spec genes of the sea urchin Stronylocentrotus purpuratus serves as an excellent model for study...
The Spec genes of the sea urchin Stronylocentrotus purpuratus serves as an excellent model for study...
PlOtp (Orthopedia), a homeodomain-containing transcription factor, has been recently characterized a...
AbstractWe show here that the homeodomain transcription factor SpOtx is required for endoderm and ab...
AbstractAn essential node in the gene regulatory network (GRN) for endomesoderm specification in the...
In the sea urchin embryo, a number of genes encoding transcription factors display territorial restr...
An essential node in the gene regulatory network (GRN) for endomesoderm specification in the sea urc...
We demonstrate that interspecific sequence conservation can provide a systematic guide to the identi...
AbstractWe demonstrate that interspecific sequence conservation can provide a systematic guide to th...
Embryonic development is coordinated by networks of evolutionary conserved regulatory genes encoding...
AbstractThe sea urchin (Hemicentrotus pulcherrimus) arylsulfatase (HpArs) gene, expressed specifical...
AbstractStrongylocentrotus purpuratus Otx (SpOtx) is required simultaneously in sea urchin developme...
To understand how a eukaryote achieves differential transcription of genes in precise spatial patter...
An important question in developmental biology is how embryonic cell types are derived from a fertil...
AbstractOrthodenticle-related (Otx) proteins are a highly conserved class of homeobox-containing tra...
The Spec genes of the sea urchin Stronylocentrotus purpuratus serves as an excellent model for study...
The Spec genes of the sea urchin Stronylocentrotus purpuratus serves as an excellent model for study...
PlOtp (Orthopedia), a homeodomain-containing transcription factor, has been recently characterized a...
AbstractWe show here that the homeodomain transcription factor SpOtx is required for endoderm and ab...
AbstractAn essential node in the gene regulatory network (GRN) for endomesoderm specification in the...
In the sea urchin embryo, a number of genes encoding transcription factors display territorial restr...
An essential node in the gene regulatory network (GRN) for endomesoderm specification in the sea urc...
We demonstrate that interspecific sequence conservation can provide a systematic guide to the identi...
AbstractWe demonstrate that interspecific sequence conservation can provide a systematic guide to th...
Embryonic development is coordinated by networks of evolutionary conserved regulatory genes encoding...
AbstractThe sea urchin (Hemicentrotus pulcherrimus) arylsulfatase (HpArs) gene, expressed specifical...