Add to ORKGProteins can make use of metal ions to bind substrates, to maintain structure, to effect catalysis, and for allosteric control and regulation. In order to hold a particular metal ion with high affinity and specificity, proteins form multidentate binding pockets designed to fulfill both the chemical and geometric bonding requirements of that metal. Metal recognition can be engineered into proteins for applications such as protein purification
SummaryMany proteins require bound metals to achieve their function. We take advantage of increasing...
AbstractMetal coordination is required for function of many proteins. For biosynthesis of proteins c...
Protein-protein interactions are ubiquitous throughout nature at many length and time scales—from tr...
Proteins can make use of metal ions to bind substrates, to maintain structure, to effect catalysis...
Metal binding provides several useful routes to protein stabilization. Metal chelation by binding si...
One of the most intriguing problems in the biological sciences is the question of how to predict pr...
The field of protein design strives to engineer new molecules that interact in a specific, controlle...
Metalloproteins are crucial for life. The mutual relationship between metal ions and proteins makes...
The de novo design of artificial metalloproteins from first-principles is a powerful strategy with w...
Selective metal coordination is central to the functions of metalloproteins:1,2 each metalloprotein ...
ABSTRACT: A semi-automated, rational design strategy has been used to introduce a family of seven si...
Creating proteins with new functions is a challenging task in the field of protein design. While var...
Selective metal binding is a key requirement not only for the functions of natural metalloproteins b...
Functional proteins designed de novo have potential application in chemical engineering, agriculture...
Simple metal-chelating sites incorporated into common elements of secondary structure located on a p...
SummaryMany proteins require bound metals to achieve their function. We take advantage of increasing...
AbstractMetal coordination is required for function of many proteins. For biosynthesis of proteins c...
Protein-protein interactions are ubiquitous throughout nature at many length and time scales—from tr...
Proteins can make use of metal ions to bind substrates, to maintain structure, to effect catalysis...
Metal binding provides several useful routes to protein stabilization. Metal chelation by binding si...
One of the most intriguing problems in the biological sciences is the question of how to predict pr...
The field of protein design strives to engineer new molecules that interact in a specific, controlle...
Metalloproteins are crucial for life. The mutual relationship between metal ions and proteins makes...
The de novo design of artificial metalloproteins from first-principles is a powerful strategy with w...
Selective metal coordination is central to the functions of metalloproteins:1,2 each metalloprotein ...
ABSTRACT: A semi-automated, rational design strategy has been used to introduce a family of seven si...
Creating proteins with new functions is a challenging task in the field of protein design. While var...
Selective metal binding is a key requirement not only for the functions of natural metalloproteins b...
Functional proteins designed de novo have potential application in chemical engineering, agriculture...
Simple metal-chelating sites incorporated into common elements of secondary structure located on a p...
SummaryMany proteins require bound metals to achieve their function. We take advantage of increasing...
AbstractMetal coordination is required for function of many proteins. For biosynthesis of proteins c...
Protein-protein interactions are ubiquitous throughout nature at many length and time scales—from tr...