There is considerable interest in determining the activation mechanism of G protein-coupled receptors (GPCRs), one of the most important types of proteins for intercellular signaling. Recently, it was demonstrated for the cannabinoid CB1 GPCR, that a single mutation T210A could make CB1 completely inactive whereas T210I makes it essentially constitutively active. To obtain an understanding of this dramatic dependence of activity on mutation, we used first-principles-based methods to predict the ensemble of low-energy seven-helix conformations for the wild-type (WT) and mutants (T210A and T210I). We find that the transmembrane (TM) helix packings depend markedly on these mutations, leading for T210A to both TM3+TM6 and TM2+TM6 salt-bridge co...
The cannabinoid receptor CB1 is a member of the G protein-coupled receptor superfamily. Signal trans...
The cannabinoid CB1 receptor, a member of the Rhodopsin (Rho) family of G protein coupled receptors...
The orphan G-protein coupled receptor (GPCR), GPR18, has been recently proposed as a potential membe...
There is considerable interest in determining the activation mechanism of G protein-coupled receptor...
Transmembrane signal transduction is achieved by activation of G protein-coupled receptors (GPCRs) ...
Transmembrane signal transduction is achieved by activation of G protein-coupled receptors (GPCRs) ...
Cells convert a diversity of extracellular signals (like hormones) into physiological responses by ...
The pleiotropy of G protein-coupled receptors (GPCRs) is enabled by their conformational flexibility...
There is increasing experimental and theoretical evidence that G protein-coupled receptors (GPCRs) ...
The role of the highly-conserved 'DRY' motif in the signaling of the CB1 cannabinoid receptor (CB1R)...
Transmembrane signal transduction is achieved by activation of G protein-coupled receptors (GPCRs) l...
In this study, we tested the hypothesis that a CB1 TMH3-4-5-6 aromatic microdomain, which includes F...
The orphan G-protein coupled receptor (GPCR), GPR18, has been recently proposed as a potential membe...
The cannabinoid receptor CB1 is a member of the G protein-coupled receptor superfamily. Signal trans...
The cannabinoid receptor CB1 is a member of the G protein-coupled receptor superfamily. Signal trans...
The cannabinoid receptor CB1 is a member of the G protein-coupled receptor superfamily. Signal trans...
The cannabinoid CB1 receptor, a member of the Rhodopsin (Rho) family of G protein coupled receptors...
The orphan G-protein coupled receptor (GPCR), GPR18, has been recently proposed as a potential membe...
There is considerable interest in determining the activation mechanism of G protein-coupled receptor...
Transmembrane signal transduction is achieved by activation of G protein-coupled receptors (GPCRs) ...
Transmembrane signal transduction is achieved by activation of G protein-coupled receptors (GPCRs) ...
Cells convert a diversity of extracellular signals (like hormones) into physiological responses by ...
The pleiotropy of G protein-coupled receptors (GPCRs) is enabled by their conformational flexibility...
There is increasing experimental and theoretical evidence that G protein-coupled receptors (GPCRs) ...
The role of the highly-conserved 'DRY' motif in the signaling of the CB1 cannabinoid receptor (CB1R)...
Transmembrane signal transduction is achieved by activation of G protein-coupled receptors (GPCRs) l...
In this study, we tested the hypothesis that a CB1 TMH3-4-5-6 aromatic microdomain, which includes F...
The orphan G-protein coupled receptor (GPCR), GPR18, has been recently proposed as a potential membe...
The cannabinoid receptor CB1 is a member of the G protein-coupled receptor superfamily. Signal trans...
The cannabinoid receptor CB1 is a member of the G protein-coupled receptor superfamily. Signal trans...
The cannabinoid receptor CB1 is a member of the G protein-coupled receptor superfamily. Signal trans...
The cannabinoid CB1 receptor, a member of the Rhodopsin (Rho) family of G protein coupled receptors...
The orphan G-protein coupled receptor (GPCR), GPR18, has been recently proposed as a potential membe...