Add to ORKGWe have initiated a research program directed toward the tetrahydroisoquinoline (THIQ) antitumor antibiotics, a class of bioactive alkaloids with existing clin. applications. Central to our approach is the development of new aryne annulation methods for the synthesis of isoquinolines. Our initial application of this method in a THIQ synthesis was to a concise asym. total synthesis of (-)-quinocarcin. Our current work in the area will be discussed
Novel heteroanthracycline antitumor drugs were designed based on structure activity relationship stu...
The construction of an isoquinoline skeleton typically starts with benzene derivatives as substrates...
A broad biological screening of the natural alkaloid N-methylisosalsoline (2) extracted from Hammada...
Described in this report is a rapid asymmetric total synthesis of the tetrahydroisoquinoline antitum...
In this tutorial review, which should be of general interest to synthetic organic chemists at large,...
A new pyridine synthesis is described. The key step involves a modified Knoevenagel-Stobbe reaction ...
The sharp rise in antimicrobial resistance has been matched by a decline in the identification and cl...
La quinocarcine, la tétrazomine et la lémonomycine constituent une sous-famille appartenant à la fam...
The last decade has seen an outgrowth in the development of synthetic methodologies exploiting benzy...
A process is described for the preparation of the core azobicyclo[7.3.1]tridecaenediyne moiety of th...
A general method for the synthesis of benz[a]anthraquinones is reported. The key step is a catalytic...
The compounds produced by a living organism are most commonly as medicinal agents and starting mater...
Nitidine and Fagaronine, two benzophenanthridine alkaloids, have shown antitumor activity in animal ...
A novel approach for the direct C-4 arylation of <i>N</i>-methyl-1,2,3,4-tetrahydroisoquinolines by ...
Herein is described our synthetic approach to the tetrahydroisoquinoline alkaloids. The first chapt...
Novel heteroanthracycline antitumor drugs were designed based on structure activity relationship stu...
The construction of an isoquinoline skeleton typically starts with benzene derivatives as substrates...
A broad biological screening of the natural alkaloid N-methylisosalsoline (2) extracted from Hammada...
Described in this report is a rapid asymmetric total synthesis of the tetrahydroisoquinoline antitum...
In this tutorial review, which should be of general interest to synthetic organic chemists at large,...
A new pyridine synthesis is described. The key step involves a modified Knoevenagel-Stobbe reaction ...
The sharp rise in antimicrobial resistance has been matched by a decline in the identification and cl...
La quinocarcine, la tétrazomine et la lémonomycine constituent une sous-famille appartenant à la fam...
The last decade has seen an outgrowth in the development of synthetic methodologies exploiting benzy...
A process is described for the preparation of the core azobicyclo[7.3.1]tridecaenediyne moiety of th...
A general method for the synthesis of benz[a]anthraquinones is reported. The key step is a catalytic...
The compounds produced by a living organism are most commonly as medicinal agents and starting mater...
Nitidine and Fagaronine, two benzophenanthridine alkaloids, have shown antitumor activity in animal ...
A novel approach for the direct C-4 arylation of <i>N</i>-methyl-1,2,3,4-tetrahydroisoquinolines by ...
Herein is described our synthetic approach to the tetrahydroisoquinoline alkaloids. The first chapt...
Novel heteroanthracycline antitumor drugs were designed based on structure activity relationship stu...
The construction of an isoquinoline skeleton typically starts with benzene derivatives as substrates...
A broad biological screening of the natural alkaloid N-methylisosalsoline (2) extracted from Hammada...