Self-Healing Tile Sets

Biology provides the synthetic chemist with a tantalizing and frustrating challenge: to create complex objects, defined from the molecular scale up to meters, that construct themselves from elementary components, and perhaps even reproduce themselves. This is the challenge of bottom-up fabrication. The most compelling answer to this challenge was formulated in the early 1980s by Ned Seeman, who realized that the information carried by DNA strands provides a means to program molecular self-assembly, with potential applications including DNA scaffolds for crystallography [19] or for molecular electronic circuits [15]. This insight opened the doors to engineering with the rich set of phenomena available in nucleic acid chemistry [20]