Recently, profile context-sensitive HMMs (profile-csHMMs) have been proposed which are very effective in modeling the common patterns and motifs in related symbol sequences. Profile-csHMMs are capable of representing long-range correlations between distant symbols, even when these correlations are entangled in a complicated manner. This makes profile-csHMMs an useful tool in computational biology, especially in modeling noncoding RNAs (ncRNAs) and finding new ncRNA genes. However, a profile-csHMM based search is quite slow, hence not practical for searching a large database. In this paper, we propose a practical scheme for making the search speed significantly faster without any degradation in the prediction accuracy. The proposed method ...
Motivation: Non-coding RNAs (ncRNAs)—functional RNA molecules not coding for proteins—are grouped in...
Profile hidden Markov models (pHMMs) are currently the most popular modeling concept for protein fam...
Non-coding RNAs (ncRNA) are RNA molecules that function in the cells without being translated into p...
The profile hidden Markov model is a specific type of HMM that is well suited for describing the com...
The profile hidden Markov model is a specific type of HMM that is well suited for describing the com...
Systematic research on noncoding RNAs (ncRNAs) has revealed that many ncRNAs are actively involved i...
Many noncoding RNAs (ncRNAs) have characteristic secondary structures that give rise to complicated ...
Beckstette M, Homann R, Giegerich R, Kurtz S. Significant speedup of database searches with HMMs by ...
Motivation: Non-coding RNAs (ncRNAs)---functional RNA molecules not coding for proteins---are groupe...
AbstractPosition-specific scoring matrices are a popular choice for modelling signals or motifs in b...
Motivation: Non-coding RNAs (ncRNAs) are functional RNA mole-cules that do not code for proteins. Co...
Abstract Background Profile hidden Markov models (profile-HMMs) are sensitive tools for remote prote...
Sequence alignment and database searching are essential tools in biology because a protein's functio...
The hidden Markov model is well-known for its efficiency in modeling short-term dependencies between...
Motivation: Profile hiddenMarkov models (pHMMs) are currently the most popular modeling concept for ...
Motivation: Non-coding RNAs (ncRNAs)—functional RNA molecules not coding for proteins—are grouped in...
Profile hidden Markov models (pHMMs) are currently the most popular modeling concept for protein fam...
Non-coding RNAs (ncRNA) are RNA molecules that function in the cells without being translated into p...
The profile hidden Markov model is a specific type of HMM that is well suited for describing the com...
The profile hidden Markov model is a specific type of HMM that is well suited for describing the com...
Systematic research on noncoding RNAs (ncRNAs) has revealed that many ncRNAs are actively involved i...
Many noncoding RNAs (ncRNAs) have characteristic secondary structures that give rise to complicated ...
Beckstette M, Homann R, Giegerich R, Kurtz S. Significant speedup of database searches with HMMs by ...
Motivation: Non-coding RNAs (ncRNAs)---functional RNA molecules not coding for proteins---are groupe...
AbstractPosition-specific scoring matrices are a popular choice for modelling signals or motifs in b...
Motivation: Non-coding RNAs (ncRNAs) are functional RNA mole-cules that do not code for proteins. Co...
Abstract Background Profile hidden Markov models (profile-HMMs) are sensitive tools for remote prote...
Sequence alignment and database searching are essential tools in biology because a protein's functio...
The hidden Markov model is well-known for its efficiency in modeling short-term dependencies between...
Motivation: Profile hiddenMarkov models (pHMMs) are currently the most popular modeling concept for ...
Motivation: Non-coding RNAs (ncRNAs)—functional RNA molecules not coding for proteins—are grouped in...
Profile hidden Markov models (pHMMs) are currently the most popular modeling concept for protein fam...
Non-coding RNAs (ncRNA) are RNA molecules that function in the cells without being translated into p...