Add to ORKGA series of compounds has been tested for effectiveness in lowering the melting temperature of poly A and of thymus DNA. The order of increasing activity was found to be: adonitol, methyl riboside (both negligible) < cyclohexanol < phenol, pyrimidine, uridine < cytidine, thymidine < purine, adenosine, inosine, deoxyguanosine < caffeine, coumarin, 2,6-dichloro-7-methylpurine. Urea was ineffective with poly A and only slightly effective with DNA. At a concentration of 0.3 M, purine lowered the Tm of DNA about 9°
This thesis is divided into three sections. The first part deals with the secondary structure of pol...
The high degree of specificity of base interactions of complementary polynucleotides is a fundamenta...
To investigate the influence of the pyrimidine 2-keto group on selection of nucleotides for incorpor...
This thesis explores the effect of chemical nucleoside modification on the physicochemical and biolo...
ABSTRACT: The R N A genomes of a number of pathogenic R N A viruses, such as HIV-1, have extensive f...
Some of the previous work on the mechanism of action of streptomycin has indicated the general area ...
In an effort to understand the factors which may contribute to the stabilization of nucleic acids as...
An alternating copolymer of deoxy 2,6 diamino purine and thymine (dDAP-T) has been synthesized by su...
In the human body, DNA-linked colloidal assemblies are prone to cleavage by nucleases, yielding the ...
AbstractIt is shown that native and denatured DNA form complexes with the oligopeptide-antibiotic di...
The search for selective interactions between nucleic acids and amino acids has for many years been ...
This thesis is based on six research publications concerned with (i) study of the molecular structur...
Synthetic nucleosides and purine analogs have been used to study the catalytic activity of DNA-depen...
The effect of a series of aminooxy analogues of the biogenic polyamines spermidine and spermine on t...
Deoxyribonucleic acid and ribonucleic acid under physiological condition are polyanions composed of ...
This thesis is divided into three sections. The first part deals with the secondary structure of pol...
The high degree of specificity of base interactions of complementary polynucleotides is a fundamenta...
To investigate the influence of the pyrimidine 2-keto group on selection of nucleotides for incorpor...
This thesis explores the effect of chemical nucleoside modification on the physicochemical and biolo...
ABSTRACT: The R N A genomes of a number of pathogenic R N A viruses, such as HIV-1, have extensive f...
Some of the previous work on the mechanism of action of streptomycin has indicated the general area ...
In an effort to understand the factors which may contribute to the stabilization of nucleic acids as...
An alternating copolymer of deoxy 2,6 diamino purine and thymine (dDAP-T) has been synthesized by su...
In the human body, DNA-linked colloidal assemblies are prone to cleavage by nucleases, yielding the ...
AbstractIt is shown that native and denatured DNA form complexes with the oligopeptide-antibiotic di...
The search for selective interactions between nucleic acids and amino acids has for many years been ...
This thesis is based on six research publications concerned with (i) study of the molecular structur...
Synthetic nucleosides and purine analogs have been used to study the catalytic activity of DNA-depen...
The effect of a series of aminooxy analogues of the biogenic polyamines spermidine and spermine on t...
Deoxyribonucleic acid and ribonucleic acid under physiological condition are polyanions composed of ...
This thesis is divided into three sections. The first part deals with the secondary structure of pol...
The high degree of specificity of base interactions of complementary polynucleotides is a fundamenta...
To investigate the influence of the pyrimidine 2-keto group on selection of nucleotides for incorpor...