Add to ORKGWe report that feeding Drosophila throughout adulthood with 4-phenylbutyrate (PBA) can significantly increase lifespan, without diminution of locomotor vigor, resistance to stress, or reproductive ability. Treatment for a limited period, either early or late in adult life, is also effective. Flies fed PBA show a global increase in histone acetylation as well as a dramatically altered pattern of gene expression, including induction or repression of numerous genes. The delay in aging may result from the altered physiological state
Dietary restriction (DR) is a widely conserved intervention leading to lifespan extension. Despite c...
Population aging has become one of the greatest worldwide challenges. Dietary restriction is believe...
Reduced methionine (Met) intake can extend lifespan of rodents, but whether this regimen represents ...
We report that feeding Drosophila throughout adulthood with 4-phenylbutyrate (PBA) can significantly...
Dietary restriction (DR), defined as a moderate reduction in food intake short of malnutrition, has ...
Why do we age? Most organisms undergo senescence, a process involving progressive functional decline...
The life history trade off between longevity and reproduction is seen in a variety of animals. In th...
The fruit fly Drosophila melanogaster offers a host of advantages for studying the biology of aging:...
As muscle function deteriorates with age, the discovery of new ways to enhance the quality of human ...
In many species, reducing nutrient intake without causing malnutrition extends lifespan 1, 2, 3. Lik...
Aging is a multifactorial process which affects all animals. Aging as a result of damage accumulatio...
The research presented here involves behavioural, pharmacological, genetic, and molecular biological...
Activation of AMP activated protein kinase (AMPK) signaling has been demonstrated to extend lifespan...
We are interested in how aging genes interact with environmental factors to promote lifespan. Dietar...
Genetic studies indicate that aging is modulated by a great number of genetic pathways. We have used...
Dietary restriction (DR) is a widely conserved intervention leading to lifespan extension. Despite c...
Population aging has become one of the greatest worldwide challenges. Dietary restriction is believe...
Reduced methionine (Met) intake can extend lifespan of rodents, but whether this regimen represents ...
We report that feeding Drosophila throughout adulthood with 4-phenylbutyrate (PBA) can significantly...
Dietary restriction (DR), defined as a moderate reduction in food intake short of malnutrition, has ...
Why do we age? Most organisms undergo senescence, a process involving progressive functional decline...
The life history trade off between longevity and reproduction is seen in a variety of animals. In th...
The fruit fly Drosophila melanogaster offers a host of advantages for studying the biology of aging:...
As muscle function deteriorates with age, the discovery of new ways to enhance the quality of human ...
In many species, reducing nutrient intake without causing malnutrition extends lifespan 1, 2, 3. Lik...
Aging is a multifactorial process which affects all animals. Aging as a result of damage accumulatio...
The research presented here involves behavioural, pharmacological, genetic, and molecular biological...
Activation of AMP activated protein kinase (AMPK) signaling has been demonstrated to extend lifespan...
We are interested in how aging genes interact with environmental factors to promote lifespan. Dietar...
Genetic studies indicate that aging is modulated by a great number of genetic pathways. We have used...
Dietary restriction (DR) is a widely conserved intervention leading to lifespan extension. Despite c...
Population aging has become one of the greatest worldwide challenges. Dietary restriction is believe...
Reduced methionine (Met) intake can extend lifespan of rodents, but whether this regimen represents ...