Add to ORKGThe N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue. Similar but distinct versions of the N-end rule operate in all organisms examined, from mammals to fungi and bacteria. In eukaryotes, the N-end rule pathway is a part of the ubiquitin system. I discuss the mechanisms and functions of this pathway, and consider its applications
Eukaryotes have evolved the ubiquitin (Ub)/proteasome system to degrade polypeptides. The Ub/proteas...
The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue....
We describe a method that can be used to produce equimolar amounts of two or more specific proteins ...
The N-end rule relates the in vivo half-life I of a protein to the identity of its N-terminal residu...
The activity and abundance of proteins within a cell are controlled precisely to ensure the regulat...
The N-end rule links the identity of the N-terminal amino acid of a protein to its in vivo half life...
AbstractIntracellular proteolysis is a tightly regulated process responsible for the targeted remova...
The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue....
The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal amino ac...
The N-end rule relates the in vivo half-life of a protein to the identity of its amino-terminal resi...
The N-end rule pathway is a highly conserved process that operates in many different organisms. It r...
The ubiquitin-dependent N-end rule pathway targets proteins for degradation through their destabiliz...
The N-end rule relates the metabolic stability of a protein to the identity of its amino-terminal re...
Regulation of the in vivo half-lives of intracellular proteins is an important cellular process. Man...
The N-end rule relates the regulation of the in vivo half-life of a protein to the identity of its N...
Eukaryotes have evolved the ubiquitin (Ub)/proteasome system to degrade polypeptides. The Ub/proteas...
The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue....
We describe a method that can be used to produce equimolar amounts of two or more specific proteins ...
The N-end rule relates the in vivo half-life I of a protein to the identity of its N-terminal residu...
The activity and abundance of proteins within a cell are controlled precisely to ensure the regulat...
The N-end rule links the identity of the N-terminal amino acid of a protein to its in vivo half life...
AbstractIntracellular proteolysis is a tightly regulated process responsible for the targeted remova...
The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue....
The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal amino ac...
The N-end rule relates the in vivo half-life of a protein to the identity of its amino-terminal resi...
The N-end rule pathway is a highly conserved process that operates in many different organisms. It r...
The ubiquitin-dependent N-end rule pathway targets proteins for degradation through their destabiliz...
The N-end rule relates the metabolic stability of a protein to the identity of its amino-terminal re...
Regulation of the in vivo half-lives of intracellular proteins is an important cellular process. Man...
The N-end rule relates the regulation of the in vivo half-life of a protein to the identity of its N...
Eukaryotes have evolved the ubiquitin (Ub)/proteasome system to degrade polypeptides. The Ub/proteas...
The N-end rule relates the in vivo half-life of a protein to the identity of its N-terminal residue....
We describe a method that can be used to produce equimolar amounts of two or more specific proteins ...