Recognition of Ribosomal RNA Sites in DNA, I. Analysis of the E. coli System

The evidence recently presented of specific hybridization between bacterial ribosomal RNA and homologous DNA1-3 has indicated the possibility of a biochemical approach to the problem of the identification of ribosomal RNA sites in DNA. A difficulty in this approach is that while the specific role of the RNA in the hybridization is open to experimental test, the critical evidence of the unique involvement of presumptive DNA sites is not easily attainable