The main theme of this PhD-thesis is the observation of clusters of galaxies at submillimetric wavelengths. The Sunyaev-Zel'dovich (SZ) effect due to interaction of cosmic microwave background (CMB) photons with electrons of the hot intra-cluster medium causes a distinct modulation in the spectrum of the CMB and is a very promising tool for detecting clusters out to very large distances. Especially the European PLANCK-mission, a satellite dedicated to the mapping of CMB anisotropies, will be the first experiment to routinely detect clusters of galaxies by their SZ-signature. This thesis presents an extensive simulation of PLANCK's SZ-capabilities, that combines all-sky maps of the SZ-effect with a realisation of the fluctuating CMB and subm...