The concept of the meme has promised to transform our understanding of culture in the same manner as the gene has transformed our knowledge of biology. Yet, memetics has failed to live up to its promise of delivering a more complex and complete model of culture. This paper addresses why the science of memetics has failed to live up to its early promise. It assesses memetics\u27 contribution to explanatory targets of culture, marketing and advertising. The paper analyzes why memetics has received a more positive reception among physical and mathematical sciences than from the social sciences. The social sciences have not been especially receptive to memetics\u27 two over-arching theoretical metaphors of genetics and of viruses of the mind....