Syntheses of mono- and diamide cross -bridged cyclens and syntheses of bifunctional chelators based upon cross -bridged tetraamine macrocycles

The syntheses of two diamide cross-bridged cyclens (22 and 23) and three monoamide cross-bridged cyclens (24, 25, and 26) are presented. Metal (Li(I), Zn(II), and Cu(II)) coordination studies of 26 are also presented. Evidence suggests that ligand 26 forms intermolecular complexes through the oxygen of an amide with Li(I), Zn(II), and Cu(II), and 26 could form complex with Li(I) through the nitrogen of an amide.*. Appropriate cross-bridged tetraamine macrocycles are promising bifunctional chelators (BFC). Improved synthesis of one BFC (36) is presented, alternative synthesis of one BFC (39) is also presented, the synthesis of a precursor of one BFC (42), the attempted syntheses of four BFCs (40, 41, 43 and 44) and the syntheses of two BFCs (45 and 46) are also presented.*