Hematopoetic neoplasia or clam hemocyte cancer (a leukemia-like disease) has been studied in a number of bivalve molluscs for the last 20 years. Recent molecular studies of the hemocytes of the soft shell clam, Mya arenaria, have demonstrated an interaction between p53 and mortalin, the mitochondrial Hsp70. The former protein is intimately involved in the initiation of cell-cycle arrest, apoptosis, DNA repair, and cell differentiation. In cancerous clams, wild-type p53 is sequestered in hemocyte cytoplasm by mortalin and cannot be translocated to the nucleus. This is critical because although p53 is functions properly, it is unable to enter the nucleus and initiate cell-cycle arrest. This allows the immortality of cancerous clam hemocytes ...
The tumor suppressor protein, p53, is an important cell cycle regulator in humans. Over half of all ...
In 1999, examination of soft-shell clam (Mya arenaria) mortalities at an experimental lease on Princ...
Clonally transmissible cancers are tumour lineages that are transmitted between individuals via the ...
The molecular mechanisms by which haemocytes of clams are transformed in the course of haemic neopla...
Cytoplasmic sequestration of p53, possibly caused by p53 interacting with mortalin, can prevent p53 ...
Mortalin, also known as mthsp70/GRP75/PBP74, interacts with the tumor suppressor protein p53 and ina...
A high prevalence of gonadal tumors has been documented in several populations of softshell clams (M...
Mya arenaria (L.) is susceptible to the disease, hematopoietic neoplasia (Hn), in which atypical cel...
AbstractPrevious studies have shown that the mammalian mitochondrial 70 kDa heat-shock protein (mort...
SummaryOutbreaks of fatal leukemia-like cancers of marine bivalves throughout the world have led to ...
Gonadal tumors in the soft-shell clam, Mya arenaria, have been observed in certain eastern Maine pop...
In North America, a high mortality of soft-shell clams Mya arenaria was found to be related to the d...
AbstractIn North America, a high mortality of soft-shell clams Mya arenaria was found to be related ...
Heamic neoplasia or disseminated neoplasia is a leukemia-like disease that consists of the prolifera...
Dept. of Medical Science/박사ABSTRACTMolecular mechanism of the role of Mortalin in human cancers: val...
The tumor suppressor protein, p53, is an important cell cycle regulator in humans. Over half of all ...
In 1999, examination of soft-shell clam (Mya arenaria) mortalities at an experimental lease on Princ...
Clonally transmissible cancers are tumour lineages that are transmitted between individuals via the ...
The molecular mechanisms by which haemocytes of clams are transformed in the course of haemic neopla...
Cytoplasmic sequestration of p53, possibly caused by p53 interacting with mortalin, can prevent p53 ...
Mortalin, also known as mthsp70/GRP75/PBP74, interacts with the tumor suppressor protein p53 and ina...
A high prevalence of gonadal tumors has been documented in several populations of softshell clams (M...
Mya arenaria (L.) is susceptible to the disease, hematopoietic neoplasia (Hn), in which atypical cel...
AbstractPrevious studies have shown that the mammalian mitochondrial 70 kDa heat-shock protein (mort...
SummaryOutbreaks of fatal leukemia-like cancers of marine bivalves throughout the world have led to ...
Gonadal tumors in the soft-shell clam, Mya arenaria, have been observed in certain eastern Maine pop...
In North America, a high mortality of soft-shell clams Mya arenaria was found to be related to the d...
AbstractIn North America, a high mortality of soft-shell clams Mya arenaria was found to be related ...
Heamic neoplasia or disseminated neoplasia is a leukemia-like disease that consists of the prolifera...
Dept. of Medical Science/박사ABSTRACTMolecular mechanism of the role of Mortalin in human cancers: val...
The tumor suppressor protein, p53, is an important cell cycle regulator in humans. Over half of all ...
In 1999, examination of soft-shell clam (Mya arenaria) mortalities at an experimental lease on Princ...
Clonally transmissible cancers are tumour lineages that are transmitted between individuals via the ...