Bleomycin is an antineoplastic drug that causes DNA damage by intra- and inter-strand crosslink and DNA strand breaks. This drug is used to treat several types of cancer. The aim of this work is to study the effect of Bleomycin on S. cerevisiae cells and select bleomycin-resistant cells to study the process of resistance acquisition to establish new protocols in in vitro drugs exposure.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech
Bleomycin (BLM) is a glycopeptide antibiotic and anti-tumor agent that targets primarily the furanos...
The antitumor activity of bleomycin is thought to arise from its ability to mediate DNA damage. Prev...
Quantification of the DNA damage induced by chemotherapy in patient cells may aid in personalization...
Tumor cells can simultaneously acquire resistance against a diverse group of drugs. This phenomenon ...
To establish, characterize and elucidate potential mechanisms of acquired bleomycin (BLM) resistance...
The budding yeast (S. cerevisiae) is an excellent eukaryotic model to study the antineoplastic drugs...
The identification of genes involved in chronological aging could have a potential utility as molecu...
The authors tried to determine a dose effect relation between the concentration of bleomycin and the...
La bléomycine est un antibiotique cytotoxique, son potentiel génotoxique est plus important quand el...
S. cerevisiae acquires bleomycin resistance after a long-term exposure to this drug which causes ove...
Bleamycin-induced chromosomal instability, generally referred to as mutagen sensitivity, is associat...
Bleomycin has been used successfully in the treatment of haemangioma, keloid and vascular malformati...
AbstractThe protein coded by a bleomycin-resistance gene (ble) cloned from producing actinomycetes w...
abstract: The bleomycins are a family of glycopeptide-derived antibiotics isolated from various Stre...
After reaction of DNA with high concentrations of bleomycin, approximately 80% of the DNA becomes tr...
Bleomycin (BLM) is a glycopeptide antibiotic and anti-tumor agent that targets primarily the furanos...
The antitumor activity of bleomycin is thought to arise from its ability to mediate DNA damage. Prev...
Quantification of the DNA damage induced by chemotherapy in patient cells may aid in personalization...
Tumor cells can simultaneously acquire resistance against a diverse group of drugs. This phenomenon ...
To establish, characterize and elucidate potential mechanisms of acquired bleomycin (BLM) resistance...
The budding yeast (S. cerevisiae) is an excellent eukaryotic model to study the antineoplastic drugs...
The identification of genes involved in chronological aging could have a potential utility as molecu...
The authors tried to determine a dose effect relation between the concentration of bleomycin and the...
La bléomycine est un antibiotique cytotoxique, son potentiel génotoxique est plus important quand el...
S. cerevisiae acquires bleomycin resistance after a long-term exposure to this drug which causes ove...
Bleamycin-induced chromosomal instability, generally referred to as mutagen sensitivity, is associat...
Bleomycin has been used successfully in the treatment of haemangioma, keloid and vascular malformati...
AbstractThe protein coded by a bleomycin-resistance gene (ble) cloned from producing actinomycetes w...
abstract: The bleomycins are a family of glycopeptide-derived antibiotics isolated from various Stre...
After reaction of DNA with high concentrations of bleomycin, approximately 80% of the DNA becomes tr...
Bleomycin (BLM) is a glycopeptide antibiotic and anti-tumor agent that targets primarily the furanos...
The antitumor activity of bleomycin is thought to arise from its ability to mediate DNA damage. Prev...
Quantification of the DNA damage induced by chemotherapy in patient cells may aid in personalization...
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