The role of agrin, Lrp4 and MuSK, key organizers of neuromuscular synaptogenesis, in the developing CNS is only poorly understood. We investigated the role of these proteins in cultured mouse embryonic cortical neurons from wildtype and from Lrp4- and MuSK-deficient mice. Neurons from Lrp4-deficient mice had fewer but longer primary dendrites and a decreased density of puncta containing excitatory and inhibitory synapse-associated proteins. Neurons from MuSK-deficient mice had an altered dendritic branching pattern but no change in the density of puncta stained by antibodies against synapse-associated proteins. Transfection of TM-agrin compensated the dendritic branching deficits in Lrp4-deficient but not in MuSK-deficient neurons. TM-agrin...
Agrin is an extracellular matrix protein involved in the formation of the postsynaptic apparatus of ...
Agrin is a proteoglycan secreted by motor neurite terminals that functions to initiate and maintain ...
AbstractProteins of the synaptic basal lamina are important in directing the differentiation of moto...
AbstractAgrin, a proteoglycan secreted by motoneurons, is a critical organizer of synaptic different...
Neuromuscular synapse formation requires a complex exchange of signals between motor neurons and ske...
Two recent papers reported identification of a long-sought agrin coreceptor, Lrp4 (Kim et al. in Cel...
SummaryNeuromuscular synapse formation requires a complex exchange of signals between motor neurons ...
Numerous studies suggest that the extracellular matrix protein agrin directs the formation of the po...
The low-density lipoprotein receptor-related protein 4 (LRP4) is essential in muscle fibers for the ...
Neuronal agrin, a heparan sulphate proteoglycan secreted by the α-motor neurons, promotes the format...
Agrin is a nerve-derived factor that plays an important role in the formation of the neuromuscular ...
Lrp4, the muscle receptor for neuronal Agrin, is expressed in the hippocampus and areas involved in ...
SummaryNeuromuscular junction (NMJ) formation requires precise interaction between motoneurons and m...
Agrin is a nerve-derived factor that directs neuromuscular synapse formation, however its role in re...
The motoneural control of skeletal muscle contraction requires the neuromuscular junction (NMJ), a m...
Agrin is an extracellular matrix protein involved in the formation of the postsynaptic apparatus of ...
Agrin is a proteoglycan secreted by motor neurite terminals that functions to initiate and maintain ...
AbstractProteins of the synaptic basal lamina are important in directing the differentiation of moto...
AbstractAgrin, a proteoglycan secreted by motoneurons, is a critical organizer of synaptic different...
Neuromuscular synapse formation requires a complex exchange of signals between motor neurons and ske...
Two recent papers reported identification of a long-sought agrin coreceptor, Lrp4 (Kim et al. in Cel...
SummaryNeuromuscular synapse formation requires a complex exchange of signals between motor neurons ...
Numerous studies suggest that the extracellular matrix protein agrin directs the formation of the po...
The low-density lipoprotein receptor-related protein 4 (LRP4) is essential in muscle fibers for the ...
Neuronal agrin, a heparan sulphate proteoglycan secreted by the α-motor neurons, promotes the format...
Agrin is a nerve-derived factor that plays an important role in the formation of the neuromuscular ...
Lrp4, the muscle receptor for neuronal Agrin, is expressed in the hippocampus and areas involved in ...
SummaryNeuromuscular junction (NMJ) formation requires precise interaction between motoneurons and m...
Agrin is a nerve-derived factor that directs neuromuscular synapse formation, however its role in re...
The motoneural control of skeletal muscle contraction requires the neuromuscular junction (NMJ), a m...
Agrin is an extracellular matrix protein involved in the formation of the postsynaptic apparatus of ...
Agrin is a proteoglycan secreted by motor neurite terminals that functions to initiate and maintain ...
AbstractProteins of the synaptic basal lamina are important in directing the differentiation of moto...