Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults.
- Graff, M.
- Scott, R.A.
- Justice, A.E.
- Young, K.L.
- Feitosa, M.F.
- Barata, L.
- Winkler, T.W.
- Chu, A.Y.
- Mahajan, A.
- Hadley, D.
- Xue, L.
- Workalemahu, T.
- Heard-Costa, N.L.
- den Hoed, M.
- Ahluwalia, T.S.
- Qi, Q.
- Ngwa, J.S.
- Renström, F.
- Quaye, L.
- Eicher, J.D.
- Hayes, J.E.
- Cornelis, M.
- Kutalik, Z.
- Lim, E.
- Luan, J.
- Huffman, J.E.
- Zhang, W.
- Zhao, W.
- Griffin, P.J.
- Haller, T.
- Ahmad, S.
- Marques-Vidal, P.M.
- Bien, S.A.
- Yengo, L.
- Teumer, A.
- Smith, A.V.
- Kumari, M.
- Harder, M.N.
- Justesen, J.M.
- Kleber, M.E.
- Hollensted, M.
- Lohman, K.
- Rivera, N.V.
- Whitfield, J.B.
- Zhao, J.H.
- Stringham, H.M.
- Lyytikäinen, L.-P.
- Huppertz, C.
- Willemsen, G.
- Peyrot, W.J.
- Wu, Y.
- Kristiansson, K.
- Demirkan, A.
- Grallert, H.
- Rawal, R.
- Huth, C.
- Peters, A.
- Thorand, B.
- Müller-Nurasyid, M.
- Strauch, K.
- Kilpeläinen, T.O.
- Bragg-Gresham, J.L.
- Vitart, V.
- Marten, J.
- Navarro, P.
- Bellis, C.
- Pasko, D.
- Johansson, Å.
- Snitker, S.
- Cheng, Y.C.
- Eriksson, J.
- Lim, U.
- Aadahl, M.
- Adair, L.S.
- Gieger, C.
- Holzapfel, C.
DOIAbstract
Physical activity (PA) may modify the genetic effects that give rise to increased risk of obesity. To identify adiposity loci whose effects are modified by PA, we performed genome-wide interaction meta-analyses of BMI and BMI-adjusted waist circumference and waist-hip ratio from up to 200,452 adults of European (n = 180,423) or other ancestry (n = 20,029). We standardized PA by categorizing it into a dichotomous variable where, on average, 23% of participants were categorized as inactive and 77% as physically active. While we replicate the interaction with PA for the strongest known obesity-risk locus in the FTO gene, of which the effect is attenuated by ~30% in physically active individuals compared to inactive individuals, we do not ident...
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