Genetic variants of <em>PTPN2</em> are associated with lung cancer risk: A re-analysis of eight GWASs in the TRICL-ILCCO consortium.
- Feng, Y.
- Wang, Y.
- Liu, H.
- Liu, Z.
- Mills, C.
- Han, Y.
- Hung, R.J.
- Brhane, Y.
- McLaughlin, J.
- Brennan, P.
- Bickeboeller, H.
- Rosenberger, A.
- Houlston, R.S.
- Caporaso, N.E.
- Teresa Landi, M.
- Brüske, I.
- Risch, A.
- Ye, Y.
- Wu, X.
- Christiani, D.C.
- Amos, C.I.
- Wei, Q.
DOIAbstract
The T-cell protein tyrosine phosphatase (TCPTP) pathway consists of signaling events mediated by TCPTP. Mutations and genetic variants of some genes in the TCPTP pathway are associated with lung cancer risk and survival. In the present study, we first investigated associations of 5,162 single nucleotide polymorphisms (SNPs) in 43 genes of this TCPTP pathway with lung cancer risk by using summary data of six published genome-wide association studies (GWAS) of 12,160 cases and 16,838 controls. We identified 11 independent SNPs in eight genes after correction for multiple comparisons by a false discovery rate <0.20. Then, we performed in silico functional analyses for these 11 SNPs by eQTL analysis, two of which, PTPN2 SNPs rs2847297 and rs...
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