Selenoprotein gene nomenclature.
- Regina, B.F.
- Gladyshev, V.N.
- Arner, E.S.J.
- Berry, M.J.
- Bruford, E.A.
- Burk, R.F.
- Carlson, B.A.
- Castellano, S.
- Chavatte, L.
- Conrad, M.
- Copeland, P.R.
- Diamond, A.M.
- Driscoll, D.M.
- Ferreiro, A.
- Flohé, L.
- Green, F.R.
- Guigo, R.
- Handy, D.E.
- Hatfield, D.L.
- Hesketh, J.
- Hoffmann, P.R.
- Holmgren, A.
- Hondal, R.J.
- Howard, M.T.
- Huang, K.M.
- Kim, H.Y.
- Kim, I.Y.
- Köhrle, J.
- Krol, A.
- Kryukov, G.V.
- Lee, B.J.
- Lee, B.C.
- Lei, X.G.
- Liu, Q.
- Lescure, A.
- Lobanov, A.V.
- Loscalzo, J.
- Maiorino, M.
- Mariotti, M.
- Prabhu, K.S.
- Rayman, M.P.
- Rozovsky, S.
- Salinas, G.
- Schmidt, E.E.
- Schomburg, L.
- Schweizer, U.
- Simonović, M.
- Sunde, R.A.
- Tsuji, P.A.
- Tweedie, S.
- Ursini, F.F.
- Whanger, P.D.
- Zhang, Y.
DOIAbstract
The human genome contains 25 genes coding for selenocysteine- containing proteins (selenoproteins). These proteins are involved in a variety of functions, most notably redox homeostasis. Selenoprotein enzymes with known functions are designated according to these functions: TXNRD1, TXNRD2, and TXNRD3 (thioredoxin reductases), GPX1, GPX2, GPX3, GPX4, and GPX6 (glutathione peroxidases), DIO1, DIO2, and DIO3 (iodothyronine deiodinases), MSRB1 (methionine sulfoxide reductase B1), and SEPHS2 (selenophosphate synthetase 2). Selenoproteins without known functions have traditionally been denoted by SEL or SEP symbols. However, these symbols are sometimes ambiguous and conflict with the approved nomenclature for several other genes. Therefore, there...
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