The aim of this study was to provide a comprehensive analysis of the role microRNA deregulation might play in osteosarcoma pathogenesis. Osteosarcoma cell lines were analyzed for genome wide microRNA and mRNA expression. Additionally the cell lines were characterized phenotypically using in vitro cell assays. By this means, deregulated microRNA and their potential target genes significantly correlating with the osteosarcoma cell lines’ potential to proliferate, migrate and invade were found. Moreover, microRNA and mRNA differentially expressed in osteosarcoma versus progenitor cell lines (using human osteoblasts and mesenchymal stem cell lines as references) have been identified
miRNA profile deregulation affecting downstream signaling pathways activates endpoints that represen...
Osteosarcoma is the most common primary bone tumor during childhood and adolescence. Several reports...
Osteosarcoma (OS) is a bone tumour affecting adolescents and elderly people. Unfortunately, basic tr...
Osteosarcomas are genetically complex tumors with abundant structural and numerical alterations. The...
A limited number of reports have investigated the role of microRNAs in osteosarcoma. In this study, ...
Background Studies show that abnormalities in non-coding genes can contribute to carcinogenesis; mic...
Osteosarcoma (OS) is the most common primary malignant tumor in children and adolescents. Numerous s...
BACKGROUND: Osteosarcomas are the most common primary malignant tumors of bone and show multiple and...
Osteosarcomas are the most common primary malignant tumors of bone and show multiple and complex gen...
Osteosarcomas (OS) are complex bone tumors with various genomic alterations. These alterations affec...
Abstract Background This study aimed to identify potential crucial genes and construction of microRN...
Copyright © 2012 Roman Muff et al. This is an open access article distributed under the Creative Com...
Osteosarcoma (OS) is the most common primary bone cancer in children and adolescents, but its pathog...
Osteosarcoma (OS) is an aggressive bone tumor primarily affecting children and adolescents. The etio...
Background: Osteosarcomas are the most common primary malignant tumors of bone and show multiple and...
miRNA profile deregulation affecting downstream signaling pathways activates endpoints that represen...
Osteosarcoma is the most common primary bone tumor during childhood and adolescence. Several reports...
Osteosarcoma (OS) is a bone tumour affecting adolescents and elderly people. Unfortunately, basic tr...
Osteosarcomas are genetically complex tumors with abundant structural and numerical alterations. The...
A limited number of reports have investigated the role of microRNAs in osteosarcoma. In this study, ...
Background Studies show that abnormalities in non-coding genes can contribute to carcinogenesis; mic...
Osteosarcoma (OS) is the most common primary malignant tumor in children and adolescents. Numerous s...
BACKGROUND: Osteosarcomas are the most common primary malignant tumors of bone and show multiple and...
Osteosarcomas are the most common primary malignant tumors of bone and show multiple and complex gen...
Osteosarcomas (OS) are complex bone tumors with various genomic alterations. These alterations affec...
Abstract Background This study aimed to identify potential crucial genes and construction of microRN...
Copyright © 2012 Roman Muff et al. This is an open access article distributed under the Creative Com...
Osteosarcoma (OS) is the most common primary bone cancer in children and adolescents, but its pathog...
Osteosarcoma (OS) is an aggressive bone tumor primarily affecting children and adolescents. The etio...
Background: Osteosarcomas are the most common primary malignant tumors of bone and show multiple and...
miRNA profile deregulation affecting downstream signaling pathways activates endpoints that represen...
Osteosarcoma is the most common primary bone tumor during childhood and adolescence. Several reports...
Osteosarcoma (OS) is a bone tumour affecting adolescents and elderly people. Unfortunately, basic tr...