A Genome-wide association meta-analysis of attention-deficit/hyperactivity disorder symptoms in population-based pediatric cohorts.
- Middeldorp, C.M.
- Hammerschlag, A.R.
- Ouwens, K.G.
- Groen-Blokhuis, M.M.
- St Pourcain, B.
- Greven, C.U.
- Pappa, I.
- EArly Genetics & Lifecourse Epidemiology (EAGLE) Consortium (Tiesler, C.M.
- Ang, W.
- Nolte, I.M.
- Vilor-Tejedor, N.
- Bacelis, J.
- Ebejer, J.L.
- Zhao, H.
- Davies, G.E.
- Ehli, E.A.
- Evans, D.M.
- Fedko, I.O.
- Guxens, M.
- Hottenga, J.J.
- Hudziak, J.J.
- Jugessur, A.
- Kemp, J.P.
- Krapohl, E.
- Martin, N.G.
- Murcia, M.
- Myhre, R.
- Ormel, J.
- Ring, S.M.
- Stergiakouli, E.
- Stoltenberg, C.
- Timpson, N.J.
- Trzaskowski, M.
- van der Most, P.J.
- Wang, C.
- Nyholt, D.R.
- Medland, S.E.
- Neale, B.M.
- Jacobsson, B.
- Sunyer, J.
- Hartman, C.A.
- Whitehouse, A.J.
- Pennell, C.E.
- Plomin, R.
- Davey Smith, G.
- Tiemeier, H.
- Posthuma, D.
- Boomsma, D.I.
DOIAbstract
OBJECTIVE: The aims of this study were to elucidate the influence of common genetic variants on childhood attention-deficit/hyperactivity disorder (ADHD) symptoms, to identify genetic variants that explain its high heritability, and to investigate the genetic overlap of ADHD symptom scores with ADHD diagnosis. METHOD: Within the EArly Genetics and Lifecourse Epidemiology (EAGLE) consortium, genome-wide single nucleotide polymorphisms (SNPs) and ADHD symptom scores were available for 17,666 children (<13 years of age) from nine population-based cohorts. SNP-based heritability was estimated in data from the three largest cohorts. Meta-analysis based on genome-wide association (GWA) analyses with SNPs was followed by gene-based association ...
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