International genome-wide association study consortium identifies novel loci associated with blood pressure in children and adolescents.
- Parmar, P.G.
- Taal, H.R.
- Timpson, N.J.
- Thiering, E.
- Lehtimäki, T.
- Marinelli, M.
- Lind, P.A.
- Howe, L.D.
- Verwoert, G.
- Aalto, V.
- Uitterlinden, A.G.
- Briollais, L.
- Evans, D.M.
- Wright, M.J.
- Newnham, J.P.
- Whitfield, J.B.
- Lyytikäinen, L.-P.
- Rivadeneira, F.
- Boomsma, D.I.
- Viikari, J.
- Gillman, M.W.
- St Pourcain, B.
- Hottenga, J.J.
- Montgomery, G.W.
- Hofman, A.
- Kähönen, M.
- Martin, N.G.
- Tobin, M.D.
- Raitakari, O.
- Vioque, J.
- Jaddoe, V.W.
- Jarvelin, M.R.
- Beilin, L.J.
- Heinrich, J.
- van Duijn, C.M.
- Pennell, C.E.
- Lawlor, D.A.
- Palmer, L.J.
DOIAbstract
BACKGROUND: -Our aim was to identify genetic variants associated with blood pressure (BP) in childhood and adolescence. METHODS AND RESULTS: -Genome-wide association study data from participating European ancestry cohorts of the EAGLE ( EA: rly G: enetics and L: ifecourse E: pidemiology) Consortium was meta-analysed across three 'epochs'; pre-puberty [4-7 years], puberty [8-12 years] and post-puberty [13-20 years]. Two novel loci were identified as having genome-wide associations with systolic blood pressure across specific age epochs; rs1563894 (ITGA11, located in active H3K27Ac mark and transcription factor CHiP and CpG methylation site) during pre-puberty (p = 2.86 × 10(-8)) and rs872256 during puberty (p = 8.67 × 10(...
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