Deep metabotyping of Exhaled Breath Condensate (EBC) – characterization of surrogate markers for systemic metabolism and non-invasive diagnostics in Diabetes.

The present manuscript treats problems of data analysis in the field of metabolomics. Specifically, the treatment of matrix effects in exhaled breath condensate (EBC) studies, the extended network-based annotation of m/z-features and the nature of multivariate data analysis are treated. A first link between EBC profiles and systemic metabolism is established at hand of the HuMet study – a nutritional study