The transcriptional landscape of age in human peripheral blood.
- Peters, M.J.
- Joehanes, R.
- Pilling, L.C.
- Schurmann, C.
- Conneely, K.N.
- Powell, J.
- Reinmaa, E.
- Sutphin, G.L.
- Zhernakova, A.
- Schramm, K.
- Wilson, Y.A.
- Kobes, S.
- Tukiainen, T.
- Ramos, Y.F.
- Göring, H.H.H.
- Fornage, M.
- Liu, Y.
- Gharib, S.A.
- Stranger, B.E.
- de Jager, P.L.
- Aviv, A.
- Levy, D.
- Murabito, J.M.
- Munson, P.J.
- Huan, T.
- Hofman, A.
- Uitterlinden, A.G.
- Rivadeneira, F.
- van Rooij, J.
- Stolk, L.
- Broer, L.
- Verbiest, M.M.P.J.
- Jhamai, M.
- Arp, P.
- Metspalu, A.
- Tserel, L.
- Milani, L.
- Samani, N.J.
- Peterson, P.
- Kasela, S.
- Codd, V.
- Peters, A.
- Ward-Caviness, C.K.
- Herder, C.
- Waldenberger, M.
- Roden, M.
- Singmann, P.
- Zeilinger, S.
- Illig, T.
- Homuth, G.
- Grabe, H.J.
- Völzke, H.
- Steil, L.
- Kocher, T.
- Martin, N.G.
- Smith, A.K.
- Mehta, D.
- Binder, E.B.
- Nylocks, K.M.
- Kennedy, E.M.
- Klengel, T.
- Ding, J.
- Suchy-Dicey, A.
- Enquobahrie, D.A.
- Houwing-Duistermaat, J.J.
- Slagboom, P.E.
- Helmer, Q.
- den Hollander, W.
- Raj, T.
- Oyston, L.J.
- Turner, S.T.
- Blangero, J.
- Brody, J.
- Rotter, J.I.
- Chen, Y.D.
- Kloppenburg, M.
- Bean, S.
- Bakhshi, N.
- Wang, Q.P.
- Psaty, B.M.
- Tracy, R.P.
- Montgomery, G.W.
- Meulenbelt, I.
- Ressler, K.J.
- Yang, J.
- Franke, L.
- Kettunen, J.
- Visscher, P.M.
- Neely, G.G.
- Korstanje, R.
- Hanson, R.L.
- Prokisch, H.
- Ferrucci, L.
- Esko, T.
- Teumer, A.
- van Meurs, J.B.
- Johnson, A.D.
DOIAbstract
Disease incidences increase with age, but the molecular characteristics of ageing that lead to increased disease susceptibility remain inadequately understood. Here we perform a whole-blood gene expression meta-analysis in 14,983 individuals of European ancestry (including replication) and identify 1,497 genes that are differentially expressed with chronological age. The age-associated genes do not harbor more age-associated CpG-methylation sites than other genes, but are instead enriched for the presence of potentially functional CpG-methylation sites in enhancer and insulator regions that associate with both chronological age and gene expression levels. We further used the gene expression profiles to calculate the 'transcriptomic age&...
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