Epigenome-wide association of DNA methylation markers in peripheral blood from Indian Asians and Europeans with incident type 2 diabetes: A nested case-control study.
- Chambers, J.C.
- Loh, M.
- Lehne, B.
- Drong, A.
- Kriebel, J.
- Motta, V.
- Wahl, S.
- Elliott, H.R.
- Rota, F.
- Scott, W.R.
- Zhang, W.
- Tan, S.T.
- Campanella, G.
- Chadeau-Hyam, M.
- Yengo, L.
- Richmond, R.C.
- Adamowicz-Brice, M.
- Afzal, U.
- Bozaoglu, K.
- Mok, Z.Y.
- Ng, H.K.
- Pattou, F.
- Prokisch, H.
- Rozario, M.A.
- Tarantini, L.
- Abbott, J.
- Ala-Korpela, M.
- Albetti, B.
- Ammerpohl, O.
- Bertazzi, P.A.
- Blancher, C.
- Caiazzo, R.
- Danesh, J.
- Gaunt, T.R.
- de Lusignan, S.
- Gieger, C.
- Illig, T.
- Jha, S.
- Jones, S.
- Jowett, J.
- Kangas, A.J.
- Kasturiratne, A.
- Kato, N.
- Kotea, N.
- Kowlessur, S.
- Pitkäniemi, J.
- Punjabi, P.
- Saleheen, D.
- Schafmayer, C.
- Soininen, P.
- Tai, E.S.
- Thorand, B.
- Tuomilehto, J.
- Wickremasinghe, A.R.
- Kyrtopoulos, S.A.
- Aitman, T.J.
- Herder, C.
- Hampe, J.
- Cauchi, S.
- Relton, C.L.
- Froguel, P.
- Soong, R.
- Vineis, P.
- Jarvelin, M.R.
- Scott, J.
- Grallert, H.
- Bollati, V.
- Elliott, P.
- McCarthy, M.I.
- Kooner, J.S.
DOIAbstract
BACKGROUND: Indian Asians, who make up a quarter of the world's population, are at high risk of developing type 2 diabetes. We investigated whether DNA methylation is associated with future type 2 diabetes incidence in Indian Asians and whether differences in methylation patterns between Indian Asians and Europeans are associated with, and could be used to predict, differences in the magnitude of risk of developing type 2 diabetes. METHODS: We did a nested case-control study of DNA methylation in Indian Asians and Europeans with incident type 2 diabetes who were identified from the 8-year follow-up of 25 372 participants in the London Life Sciences Prospective Population (LOLIPOP) study. Patients were recruited between May 1, 2002, and ...
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