Anaerobically cultured yeast cells have a very low HMG-CoA reductase activity and a low sterol content. When these cells are transfered to phosphate buffer containing 1.2 % glucose and held under aerobic conditions, the specific activity of the HMG-CoA reductase increases up to sixfold within 8 hrs. The increase in the reductase activity is paralled by an increase in the sterol content. This induction of HMG-CoA reductase in resting yeast cells is inhibited by cycloheximide indicating that a de novo synthesis of enzyme protein is mediated by glucose under aerobic conditions. It appears that the regulation of sterol synthesis in yeast is closely connected with the aerobic glucose metabolism
The molecular mechanisms that govern intracellular transport of sterols in eukaryotic cells are only...
Sterol sensing domain (SSD) containing proteins are required for lipid regulation, and are conserved...
Biosynthesis of sterols, which are considered essential components of virtually all eukaryotic membr...
Lipid-depleted yeast, grown anaerobically, contains only very low amounts of sterols. The hydroxymet...
Yeast is the most primitive organism synthesizing substantial amounts of sterols. Because of this eu...
tase) activity in haploid strains and diploid hybrids of wild-type Saccharomyces cerevisiae revealed...
Graduation date: 1963An enzyme system from cell-free yeast homogenates mediating the\ud transfer of ...
Sterol synthesis in liver in vivo is regulated at the site of the reaction catalyzed by 3-hydroxy-3-...
Abstract Steroidal compounds are of great interest in the pharmaceutical field, with steroidal drugs...
Graduation date:1986Sterols of the yeast Saccharomyces cerevisiae are found in\ud membranes with a f...
Sterols are essential components of eukaryotic membranes and contribute to important physiological c...
Ergosterol is an essential component of fungal cell membranes that determines the fluidity, permeabi...
It could be established that the total sterol content is an individual and reproducible characterist...
Sterols are important molecules in regulating membrane fluidity and permeability in eukaryotic cells...
Graduation date: 1983The role of the yeast S-adenosylmethionine: Δ²⁴-sterol-C-methyltransferase\ud (...
The molecular mechanisms that govern intracellular transport of sterols in eukaryotic cells are only...
Sterol sensing domain (SSD) containing proteins are required for lipid regulation, and are conserved...
Biosynthesis of sterols, which are considered essential components of virtually all eukaryotic membr...
Lipid-depleted yeast, grown anaerobically, contains only very low amounts of sterols. The hydroxymet...
Yeast is the most primitive organism synthesizing substantial amounts of sterols. Because of this eu...
tase) activity in haploid strains and diploid hybrids of wild-type Saccharomyces cerevisiae revealed...
Graduation date: 1963An enzyme system from cell-free yeast homogenates mediating the\ud transfer of ...
Sterol synthesis in liver in vivo is regulated at the site of the reaction catalyzed by 3-hydroxy-3-...
Abstract Steroidal compounds are of great interest in the pharmaceutical field, with steroidal drugs...
Graduation date:1986Sterols of the yeast Saccharomyces cerevisiae are found in\ud membranes with a f...
Sterols are essential components of eukaryotic membranes and contribute to important physiological c...
Ergosterol is an essential component of fungal cell membranes that determines the fluidity, permeabi...
It could be established that the total sterol content is an individual and reproducible characterist...
Sterols are important molecules in regulating membrane fluidity and permeability in eukaryotic cells...
Graduation date: 1983The role of the yeast S-adenosylmethionine: Δ²⁴-sterol-C-methyltransferase\ud (...
The molecular mechanisms that govern intracellular transport of sterols in eukaryotic cells are only...
Sterol sensing domain (SSD) containing proteins are required for lipid regulation, and are conserved...
Biosynthesis of sterols, which are considered essential components of virtually all eukaryotic membr...