Phosphatidylcholine (PC) and licensed formulations containing PC were tested for their influence on the proliferation and viability of cells permanently infected with HIV-1 (human immunodeficiency virus type 1). PC alone, as well as pharmaceutical formulations containing PC, selectively inhibited the growth of productively infected lymphoid cells. The strongest growth inhibition was observed with formulations containing PC, glycerol and triglyceride together. The growth inhibition was dose-dependent for HIV-1-infected cells. Additionally, PC-containing formulations dramatically reduced antigen production from peripheral blood mononuclear cells (PBMCs) infected in vitro with HIV-1. In vivo experiments with Rauscher-MuLV-infected mice showed ...
AbstractWe have investigated the effect of lysophosphatidylcholine (LPC) on fusion of cells expressi...
The anti-HIV activity of a new humic substance-derived preparation has been studied in individual po...
Macrophages are recognized as a major reservoir of HIV-1 in infected individuals. We examined the ef...
Cultured T-lymphoma cell lines H9 and KE37-1 permanently infected with human immunodeficiency virus ...
Previously, it was shown that the cell-membrane-expressed glycosphingolipid, globotriaosylceramide (...
Various new classes of compounds have been recently identified as potent and selective inhibitors of...
AbstractAccording to early experiments with natural extracts, phosphatidylcholines (PCs) are widely ...
Background: Development of topical microbicides and entry inhibitors is a promising approach to prev...
Previously we have identified the glycosphingolipid globotriaosylceramide (Gb3/Pk) as an inhibitor a...
<p>Inhibition of HIV-1 infection by PS extract was enhanced by pre-incubation of virus preparations ...
<p><b>A</b>, SIL suppresses growth of PBMC and CEM cells. Cells were treated with SIL as described i...
The capacity of the immunomodulatory drug rapamycin (RAPA) to inhibit replication of the CCR5 strain...
<p><b>A</b>, SIL inhibits LAI and BAL infection of PBMCs derived from 5 different donors. PBMC were ...
Because of the importance of monocytes/macrophages (M/M) as an in vivo reservoir of hu-man immunodef...
The effect of exogenous phosphatidylcholine on structure and function of plasma membranes from HIV-1...
AbstractWe have investigated the effect of lysophosphatidylcholine (LPC) on fusion of cells expressi...
The anti-HIV activity of a new humic substance-derived preparation has been studied in individual po...
Macrophages are recognized as a major reservoir of HIV-1 in infected individuals. We examined the ef...
Cultured T-lymphoma cell lines H9 and KE37-1 permanently infected with human immunodeficiency virus ...
Previously, it was shown that the cell-membrane-expressed glycosphingolipid, globotriaosylceramide (...
Various new classes of compounds have been recently identified as potent and selective inhibitors of...
AbstractAccording to early experiments with natural extracts, phosphatidylcholines (PCs) are widely ...
Background: Development of topical microbicides and entry inhibitors is a promising approach to prev...
Previously we have identified the glycosphingolipid globotriaosylceramide (Gb3/Pk) as an inhibitor a...
<p>Inhibition of HIV-1 infection by PS extract was enhanced by pre-incubation of virus preparations ...
<p><b>A</b>, SIL suppresses growth of PBMC and CEM cells. Cells were treated with SIL as described i...
The capacity of the immunomodulatory drug rapamycin (RAPA) to inhibit replication of the CCR5 strain...
<p><b>A</b>, SIL inhibits LAI and BAL infection of PBMCs derived from 5 different donors. PBMC were ...
Because of the importance of monocytes/macrophages (M/M) as an in vivo reservoir of hu-man immunodef...
The effect of exogenous phosphatidylcholine on structure and function of plasma membranes from HIV-1...
AbstractWe have investigated the effect of lysophosphatidylcholine (LPC) on fusion of cells expressi...
The anti-HIV activity of a new humic substance-derived preparation has been studied in individual po...
Macrophages are recognized as a major reservoir of HIV-1 in infected individuals. We examined the ef...