Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: The CREAM consortium.
- Li, Q.
- Wojciechowski, R.
- Simpson, C.L.
- Hysi, P.G.
- Verhoeven, V.J.
- Ikram, M.K.
- Höhn, R.
- Vitart, V.
- Hewitt, A.W.
- Oexle, K.
- Mäkelä, K.M.
- MacGregor, S.
- Pirastu, M.
- Fan, Q.
- Cheng, C.Y.
- St. Pourcain, B.
- McMahon, G.
- Kemp, J.P.
- Northstone, K.
- Rahi, J.S.
- Cumberland, P.M.
- Martin, N.G.
- Sanfilippo, P.G.
- Lu, Y.
- Wang, Y.X.
- Hayward, C.
- Polasek, O.
- Campbell, H.
- Bencic, G.
- Wright, A.F.
- Wedenoja, J.
- Zeller, T.
- Schillert, A.
- Mirshahi, A.
- Lackner, K.J.
- Yip, S.P.
- Yap, M.K.H.
- Ried, J.S.
- Gieger, C.
- Murgia, F.
- Wilson, J.F.
- Fleck, B.
- Yazar, S.
- Vingerling, J.R.
- Hofman, A.
- Uitterlinden, A.
- Rivadeneira, F.
- Amin, N.
- Karssen, L.C.
- Oostra, B.A.
- Zhou, X.
- Teo, Y.Y.
- Tai, E.S.
- Vithana, E.
- Barathi, V.A.
- Zheng, Y.
- Siantar, R.G.
- Neelam, K.
- Shin, Y.K.
- Lam, J.S.Y.
- Yonova-Doing, E.
- Venturini, C.
- Hosseini, S.M.
- Wong, H.S.
- Lehtimäki, T.
- Kähönen, M.
- Raitakari, O.
- Timpson, N.J.
- Evans, D.M.
- Khor, C.C.
- Aung, T.
- Young, T.L.
- Mitchell, P.
- Klein, B.
- van Duijn, C.M.
- Meitinger, T.
- Jonas, J.B.
- Baird, P.N.
- Mackey, D.A.
- Wong, T.Y.
- Saw, S.M.
- Pärssinen, O.
- Stambolian, D.
- Hammond, C.J.
- Klaver, C.C.
- Williams, C.
- Paterson, A.D.
- Bailey-Wilson, J.E.
- Guggenheim, J.A.
DOIAbstract
To identify genetic variants associated with refractive astigmatism in the general population, meta-analyses of genome-wide association studies were performed for: White Europeans aged at least 25 years (20 cohorts, N = 31,968); Asian subjects aged at least 25 years (7 cohorts, N = 9,295); White Europeans aged <25 years (4 cohorts, N = 5,640); and all independent individuals from the above three samples combined with a sample of Chinese subjects aged <25 years (N = 45,931). Participants were classified as cases with refractive astigmatism if the average cylinder power in their two eyes was at least 1.00 diopter and as controls otherwise. Genome-wide association analysis was c...
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