The role of adiposity in cardiometabolic traits: A mendelian randomization analysis.
- Fall, T.
- Hägg, S.
- Mägi, R.
- Ploner, A.
- Fischer, K.
- Horikoshi, M.
- Sarin, A.P.
- Thorleifsson, G.
- Ladenvall, C.
- Kals, M.
- Kuningas, M.
- Draisma, H.H.
- Ried, J.S.
- van Zuydam, N.
- Huikari, V.
- Mangino, M.
- Sonestedt, E.
- Benyamin, B.
- Nelson, C.P.
- Rivera, N.V.
- Kristiansson, K.
- Shen, H.Y.
- Havulinna, A.S.
- Dehghan, A.
- Donnelly, L.A.
- Kaakinen, M.
- Nuotio, M.L.
- Robertson, N.
- de Bruijn, R.F.
- Ikram, M.A.
- Amin, N.
- Balmforth, A.J.
- Braund, P.S.
- Doney, A.S.
- Döring, A.
- Elliott, P.
- Esko, T.
- Franco, O.H.
- Gretarsdottir, S.
- Hartikainen, A.L.
- Heikkilä, K.
- Herzig, K.H.
- Holm, H.
- Hottenga, J.J.
- Hyppönen, E.
- Illig, T.
- Isaacs, A.
- Isomaa, B.
- Karssen, L.C.
- Kettunen, J.
- Koenig, W.
- Kuulasmaa, K.
- Laatikainen, T.
- Laitinen, J.
- Lindgren, C.
- Lyssenko, V.
- Läärä, E.
- Rayner, N.W.
- Männistö, S.
- Pouta, A.
- Rathmann, W.
- Rivadeneira, F.
- Ruokonen, A.
- Savolainen, M.J.
- Sijbrands, E.J.
- Small, K.S.
- Smit, J.H.
- Steinthorsdottir, V.
- Syvanen, A.C.
- Taanila, A.
- Tobin, M.D.
- Uitterlinden, A.G.
- Willems, S.M.
- Willemsen, G.
- Witteman, J.
- Perola, M.
- Evans, A.
- Ferrieres, J.
- Virtamo, J.
- Kee, F.
- Tregouet, D.A.
- Arveiler, D.
- Amouyel, P.
- Ferrario, M.M.
- Brambilla, P.
- Hall, A.S.
- Heath, A.C.
- Madden, P.A.
- Martin, N.G.
- Montgomery, G.W.
- Whitfield, J.B.
- Jula, A.
- Knekt, P.
- Oostra, B.
- van Duijn, C.M.
- Penninx, B.W.
- Davey Smith, G.
- Kaprio, J.
- Samani, N.J.
- Gieger, C.
- Peters, A.
- Wichmann, H.-E.
- Boomsma, D.I.
- de Geus, E.J.
- Tuomi, T.
- Power, C.
- Hammond, C.J.
- Spector, T.D.
- Lind, L.
- Orho-Melander, M.
- Palmer, C.N.
- Morris, A.D.
- Groop, L.
- Jarvelin, M.R.
- Salomaa, V.
- Vartiainen, E.
- Hofman, A.
- Ripatti, S.
- Metspalu, A.
- Thorsteinsdottir, U.
- Stefansson, K.
- Pedersen, N.L.
- McCarthy, M.I.
- Ingelsson, E.
- Prokopenko, I.
- ENGAGE Consortium ()
DOIAbstract
BACKGROUND: The association between adiposity and cardiometabolic traits is well known from epidemiological studies. Whilst the causal relationship is clear for some of these traits, for others it is not. We aimed to determine whether adiposity is causally related to various cardiometabolic traits using the Mendelian randomization approach. METHODS AND FINDINGS: We used the adiposity-associated variant rs9939609 at the FTO locus as an instrumental variable (IV) for body mass index (BMI) in a Mendelian randomization design. Thirty-six population-based studies of individuals of European descent contributed to the analyses. Age- and sex-adjusted regression models were fitted to test for association between (i) rs9939609 and BMI (n = 198,502), ...
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