Humanization of immunosuppressive anti-T cell monoclonal antibodies (mAb) raises the question as to how completely it helps to avoid formation of neutralizing anti-antibodies (anti-Ab) in patients. To get more information on intra-species sensitization against anti-T cell mAb, we produced two immunosuppressive mouse IgG2a anti-mouse Thy-1.2 mAb (MmT1 and MmT5) in AKR/J mice and measured the potential of MmT1 to elicit inhibitory anti-Ab in AKR/J (H-2k), C57BL/6 (H-2b), congenic B10.BR (H-2k) and DBA/2 (H-2d) mice. After one injection once weekly for 4 weeks of 5 micrograms MmT1 (200 micrograms/kg) in C57BL/6 mice, without the use of any adjuvants, high concentrations of anti-Ab directed against MmT1 (300 micrograms/ml) and MmT5 (100 microgr...
Therapeutic monoclonal antibodies (mAbs) such as the superagonistic, CD28-specific antibody TGN1412,...
Murine experimental autoimmune thyroiditis (EAT), is used as a model for human autoimmune thyroid di...
Autoimmune NZB/NZW mice were treated with weekly injections of monoclonal antibody (mAb) to L3T4, an...
Humanization of immunosuppressive anti-T cell monoclonal antibodies (mAb) raises the question as to ...
The development of anti-drug-antibodies (ADA) to biopharmaceuticals, e.g. recombinant proteins inclu...
Formation of anti-antibodies (anti-Ab) is known to counteract immunotherapy with anti-T cell antibod...
The antiglobulin (anti-Ig) response to therapeutic monoclonal antibodies (mAbs) poses a significant ...
Antibodies against T cells are widely used as immunosuppressive agents in clinical therapy. As effec...
<p>WT and AID<sup>−/−</sup> mice were immunized with recombinant human MOG (rhMOG) and titres of ant...
Humanized mice historically have not been good models of human humoral immunity induced by either in...
In organ transplantation, human leukocyte antigen (HLA)-mismatch grafts not only induce the activati...
BACKGROUND: Therapeutic antibody development is one of the fastest growing areas of the pharmaceutic...
Therapeutic antibody development is one of the fastest growing areas of the pharmaceutical industry....
Monoclonal antibodies (mAb) directed against the clonotypic structure of the T-cell receptor (TCR) m...
BACKGROUND: Passive transfer of antibodies not only provides immediate short-term protection against...
Therapeutic monoclonal antibodies (mAbs) such as the superagonistic, CD28-specific antibody TGN1412,...
Murine experimental autoimmune thyroiditis (EAT), is used as a model for human autoimmune thyroid di...
Autoimmune NZB/NZW mice were treated with weekly injections of monoclonal antibody (mAb) to L3T4, an...
Humanization of immunosuppressive anti-T cell monoclonal antibodies (mAb) raises the question as to ...
The development of anti-drug-antibodies (ADA) to biopharmaceuticals, e.g. recombinant proteins inclu...
Formation of anti-antibodies (anti-Ab) is known to counteract immunotherapy with anti-T cell antibod...
The antiglobulin (anti-Ig) response to therapeutic monoclonal antibodies (mAbs) poses a significant ...
Antibodies against T cells are widely used as immunosuppressive agents in clinical therapy. As effec...
<p>WT and AID<sup>−/−</sup> mice were immunized with recombinant human MOG (rhMOG) and titres of ant...
Humanized mice historically have not been good models of human humoral immunity induced by either in...
In organ transplantation, human leukocyte antigen (HLA)-mismatch grafts not only induce the activati...
BACKGROUND: Therapeutic antibody development is one of the fastest growing areas of the pharmaceutic...
Therapeutic antibody development is one of the fastest growing areas of the pharmaceutical industry....
Monoclonal antibodies (mAb) directed against the clonotypic structure of the T-cell receptor (TCR) m...
BACKGROUND: Passive transfer of antibodies not only provides immediate short-term protection against...
Therapeutic monoclonal antibodies (mAbs) such as the superagonistic, CD28-specific antibody TGN1412,...
Murine experimental autoimmune thyroiditis (EAT), is used as a model for human autoimmune thyroid di...
Autoimmune NZB/NZW mice were treated with weekly injections of monoclonal antibody (mAb) to L3T4, an...