The success of a vaccine consists in the induction of an innate immune response and subsequent activation of the adaptive immune system. Because antigens are usually not immunogenic, the addition of adjuvants that activate innate immunity is required. The mycobacterial cord factor trehalose-6,6'-dimycolate (TDM) and its synthetic adjuvant analogue trehalose-6,6'-dibehenate (TDB) rely on the C-type lectin Mincle and the signaling molecules Syk and Card9 to trigger innate immunity. In this study, we show that stimulation of bone marrow-derived dendritic cells (BMDCs) with TDB induces Nlrp3 inflammasome-dependent IL-1β secretion. While Card9 is required for NF-κB activation by TDB, it is dispensable for TDB-induced activatio...
International audienceGroup B Streptococcus (GBS) is a frequent agent of life-threatening sepsis and...
The cell wall of mycobacteria is characterised by glycolipids composed of different classes of mycol...
The T-cell adjuvanticity of mycobacterial cord factor trehalose 6,6'-dimycolate (TDM) is well establ...
The success of a vaccine consists in the induction of an innate immune response and subsequent activ...
Successful vaccination against intracellular pathogens requires the generation of cellular immune re...
Successful vaccination against intracellular pathogens requires the generation of cellular immune re...
Successful vaccination against intracellular pathogens requires the generation of cellular immune re...
Although adjuvants are critical vaccine components, their modes of action are poorly understood. Thi...
The mycobacterial cord factor trehalose-6,6-dimycolate (TDM) and its synthetic analog trehalose-6,6-...
Gram-positive bacterial infections have risen over recent years and current antibiotic treatments ar...
The mycobacterial cord factor trehalose-6,6-dimycolate (TDM) and its synthetic analog trehalose-6,6-...
SummaryCord factor, also called trehalose-6,6′-dimycolate (TDM), is a potent mycobacterial adjuvant....
Although adjuvants are critical vaccine components, their modes of action are poorly understood. Her...
<p>The cell wall of mycobacteria is characterised by glycolipids composed of different classes...
The mycobacterial cord factor trehalose-6,6’-dimycolate (TDM) is an abundant cell wall glycolipid of...
International audienceGroup B Streptococcus (GBS) is a frequent agent of life-threatening sepsis and...
The cell wall of mycobacteria is characterised by glycolipids composed of different classes of mycol...
The T-cell adjuvanticity of mycobacterial cord factor trehalose 6,6'-dimycolate (TDM) is well establ...
The success of a vaccine consists in the induction of an innate immune response and subsequent activ...
Successful vaccination against intracellular pathogens requires the generation of cellular immune re...
Successful vaccination against intracellular pathogens requires the generation of cellular immune re...
Successful vaccination against intracellular pathogens requires the generation of cellular immune re...
Although adjuvants are critical vaccine components, their modes of action are poorly understood. Thi...
The mycobacterial cord factor trehalose-6,6-dimycolate (TDM) and its synthetic analog trehalose-6,6-...
Gram-positive bacterial infections have risen over recent years and current antibiotic treatments ar...
The mycobacterial cord factor trehalose-6,6-dimycolate (TDM) and its synthetic analog trehalose-6,6-...
SummaryCord factor, also called trehalose-6,6′-dimycolate (TDM), is a potent mycobacterial adjuvant....
Although adjuvants are critical vaccine components, their modes of action are poorly understood. Her...
<p>The cell wall of mycobacteria is characterised by glycolipids composed of different classes...
The mycobacterial cord factor trehalose-6,6’-dimycolate (TDM) is an abundant cell wall glycolipid of...
International audienceGroup B Streptococcus (GBS) is a frequent agent of life-threatening sepsis and...
The cell wall of mycobacteria is characterised by glycolipids composed of different classes of mycol...
The T-cell adjuvanticity of mycobacterial cord factor trehalose 6,6'-dimycolate (TDM) is well establ...