Meta-analysis identifies multiple loci associated with kidney function-related traits in East Asian populations.
- Okada, Y.
- Sim, X.
- Go, M.J.
- Wu, J.Y.
- Gu, D.F.
- Takeuchi, F.
- Takahashi, A.
- Maeda, S.
- Tsunoda, T.
- Chen, P.
- Lim, S.C.
- Wong, T.Y.
- Liu, J.J.
- Young, T.L.
- Aung, T.
- Seielstad, M.
- Teo, Y.Y.
- Kim, Y.J.
- Lee, J.Y.
- Han, B.G.
- Kang, D.
- Chen, C.H.
- Tsai, F.J.
- Chang, L.C.
- Fann, S.J.C.
- Mei, H.
- Rao, D.C.
- Hixson, J.E.
- Chen, S.F.
- Katsuya, T.
- Isono, M.
- Ogihara, T.
- Chambers, J.C.
- Zhang, W.H.
- Kooner, J.S.
- Albrecht, E.
- Yamamoto, K.
- Kubo, M.
- Nakamura, Y.
- Kamatani, N.
- Kato, N.
- He, J.
- Chen, Y.T.
- Cho, Y.S.
- Tai, E.S.
- Tanaka, T.
DOIAbstract
Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genomewide association studies for kidney function-related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital- or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN). Our meta-analysis identified 17 loci newly associated with kidney function-related traits, including the concentrations of blood urea nitrogen, uric acid and serum creatinine and estimated glomerular filtration rate based on serum creatinine levels (eGFRcrea) (P < 5.0...
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