Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis.
- Paternoster, L.
- Standl, M.
- Chen, C.M.
- Ramasamy, A.
- Bønnelykke, K.
- Duijts, L.
- Ferreira, M.A.
- Alves, A.C.
- Thyssen, J.P.
- Albrecht, E.
- Baurecht, H.
- Feenstra, B.
- Sleiman, P.M.
- Hysi, P.
- Warrington, N.M.
- Curjuric, I.
- Myhre, R.
- Curtin, JA.
- Groen-Blokhuis, M.M.
- Kerkhof, M.
- Saaf, A.
- Franke, A.
- Ellinghaus, D.
- Fölster-Holst, R.
- Dermitzakis, E.
- Montgomery, S.B.
- Prokisch, H.
- Heim, K.
- Hartikainen, A.L.
- Pouta, A.
- Pekkanen, J.
- Blakemore, A.I.
- Buxton, J.L.
- Kaakinen, M.
- Duffy, D.L.
- Madden, P.A.
- Heath, A.C.
- Montgomery, G.W.
- Thompson, P.J.
- Matheson, M.C.
- Le, Souëf, P
- Australian Asthma Genetics Consortium (AAGC) ()
- Pourcain, B.S.
- Smith, G.D.
- Henderson, J.
- Kemp, J.P.
- Timpson, N.J.
- Deloukas, P.
- Ring, S.M.
- Wichmann, H.-E.
- Müller-Nurasyid, M.
- Novak, N.
- Klopp, N.
- Rodriguez, E.
- McArdle, W.
- Linneberg, A.
- Menne, T.
- Nohr, E.A.
- Hofman, A.
- Uitterlinden, A.G.
- van Duijn, C.M.
- Rivadeneira, F.
- de Jongste, J.C.
- van der Valk, R.J.
- Wjst, M.
- Jõgi, R.
- Geller, F.
- Boyd, H.A.
- Murray, J.C.
- Kim, C.
- Mentch, F.
- March, M.
- Mangino, M.
- Spector, T.D.
- Bataille, V.
- Pennell, C.E.
- Holt, P.G.
- Sly, P.
- Tiesler, C.M.
- Thiering, E.
- Illig, T.
- Imboden, M.
- Nystad, W.
- Simpson, A.
- Hottenga, J.J.
- Postma, D.
- Koppelman, G.H.
- Smit, H.A.
- Söderhäll, C.
- Chawes, B.
- Kreiner-Møller, E.
- Bisgaard, H.
- Melén, E.
- Boomsma, D.I.
- Custovic, A.
- Jacobsson, B.
- Probst-Hensch, N.M.
- Palmer, L.J.
- Glass, D.
- Hakonarson, H.
- Melbye, M.
- Jarvis, D.L.
- Jaddoe, V.W.
- Gieger, C.
- Genetics of Overweight Young Adults (GOYA) Consortium ()
- Strachan, D.P.
- Martin, N.G.
- Jarvelin, M.R.
- Heinrich, J.
- Evans, D.M
- EArly Genetics & Lifecourse Epidemiology (EAGLE) Consortium ()
- Weidinger, S.
DOIAbstract
Atopic dermatitis (AD) is a commonly occurring chronic skin disease with high heritability. Apart from filaggrin (FLG), the genes influencing atopic dermatitis are largely unknown. We conducted a genome-wide association meta-analysis of 5,606 affected individuals and 20,565 controls from 16 population-based cohorts and then examined the ten most strongly associated new susceptibility loci in an additional 5,419 affected individuals and 19,833 controls from 14 studies. Three SNPs reached genome-wide significance in the discovery and replication cohorts combined, including rs479844 upstream of OVOL1 (odds ratio (OR) = 0.88, P = 1.1 × 10(-13)) and rs2164983 near ACTL9 (OR = 1.16, P = 7.1 × 10(-9)), both of which are near genes that...
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