Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: First in-human results.
- van Dam, G.M.
- Themelis, G.
- Crane, L.M.
- Harlaar, N.J.
- Pleijhuis, R.G.
- Kelder, W.
- Sarantopoulos, A.
- de Jong, J.S.
- Arts, H.J.
- van der Zee, A.G.
- Bart, J.
- Low, P.S.
- Ntziachristos, V.
DOIAbstract
The prognosis in advanced-stage ovarian cancer remains poor. Tumor-specific intraoperative fluorescence imaging may improve staging and debulking efforts in cytoreductive surgery and thereby improve prognosis. The overexpression of folate receptor-α (FR-α) in 90-95% of epithelial ovarian cancers prompted the investigation of intraoperative tumor-specific fluorescence imaging in ovarian cancer surgery using an FR-α-targeted fluorescent agent. In patients with ovarian cancer, intraoperative tumor-specific fluorescence imaging with an FR-α-targeted fluorescent agent showcased the potential applications in patients with ovarian cancer for improved intraoperative staging and more radical cytoreductive surgery
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