Add to ORKGThe restless legs syndrome (RLS) is a common complex genetic neurological disorder. In this work, the first large-scale SNP-based case-control association studies of RLS identified associations to intronic and intergenic SNPs in five genomic regions. Regional studies of known linkage regions found associated variants in the genes NOS1 and PTPRD. A genome-wide study identified associated variants in three genomic regions containing the genes MEIS1, BTBD9, MAP2K5, and LBXCOR1. Each variant confers a 30 to 70% increase in disease risk and a haplotype in MEIS1 leads to an almost 3-fold increase. These variants contribute substantially to the disease prevalence but explain only a fraction of the heritability. Several of the associated genes are ...
Restless legs syndrome (RLS) is a sensorimotor disorder with an age-dependent prevalence of up to 10...
Several studies demonstrated that 60% of restless legs syndrome (RLS) patients have a positive famil...
Restless legs syndrome (RLS) is a common neurologic sensorimotor disorder often described as an unpl...
Restless legs syndrome (RLS) is a frequent neurological disorder characterized by an imperative urge...
Restless legs syndrome (RLS) is a highly familial trait with heritability estimates of about 50%. It...
Restless legs syndrome (RLS) is a common neurological sensorimotor disorder often described as an un...
Background Restless legs syndrome is a prevalent chronic neurological disorder with potentially seve...
Background Restless legs syndrome is a prevalent chronic neurological disorder with potentially seve...
Restless legs syndrome (RLS) is a common neurological disorder that affects 5%–12% of all whites. To...
Restless legs syndrome (RLS) is associated with common variants in three intronic and intergenic reg...
Restless legs syndrome (RLS) is a common neurologic condition characterized by nocturnal dysesthesia...
Restless legs syndrome (RLS) is a common neurologic condition characterized by nocturnal dysesthesia...
Restless legs syndrome (RLS) is a common neurologic disorder classically characterized by dysesthesi...
BACKGROUND: Restless legs syndrome is a prevalent chronic neurological disorder with potentially sev...
Restless legs syndrome (RLS) is a sensorimotor disorder with an age-dependent prevalence of up to 10...
Restless legs syndrome (RLS) is a sensorimotor disorder with an age-dependent prevalence of up to 10...
Several studies demonstrated that 60% of restless legs syndrome (RLS) patients have a positive famil...
Restless legs syndrome (RLS) is a common neurologic sensorimotor disorder often described as an unpl...
Restless legs syndrome (RLS) is a frequent neurological disorder characterized by an imperative urge...
Restless legs syndrome (RLS) is a highly familial trait with heritability estimates of about 50%. It...
Restless legs syndrome (RLS) is a common neurological sensorimotor disorder often described as an un...
Background Restless legs syndrome is a prevalent chronic neurological disorder with potentially seve...
Background Restless legs syndrome is a prevalent chronic neurological disorder with potentially seve...
Restless legs syndrome (RLS) is a common neurological disorder that affects 5%–12% of all whites. To...
Restless legs syndrome (RLS) is associated with common variants in three intronic and intergenic reg...
Restless legs syndrome (RLS) is a common neurologic condition characterized by nocturnal dysesthesia...
Restless legs syndrome (RLS) is a common neurologic condition characterized by nocturnal dysesthesia...
Restless legs syndrome (RLS) is a common neurologic disorder classically characterized by dysesthesi...
BACKGROUND: Restless legs syndrome is a prevalent chronic neurological disorder with potentially sev...
Restless legs syndrome (RLS) is a sensorimotor disorder with an age-dependent prevalence of up to 10...
Restless legs syndrome (RLS) is a sensorimotor disorder with an age-dependent prevalence of up to 10...
Several studies demonstrated that 60% of restless legs syndrome (RLS) patients have a positive famil...
Restless legs syndrome (RLS) is a common neurologic sensorimotor disorder often described as an unpl...