This unit provides an overview of the major types of mutant alleles that can be generated by gene targeting in ES cells. It presents the growing public resources of premade gene targeting vectors, modified ES cells, and mutant mice. General guidelines for the design of targeting vectors are followed by protocols for the construction of vectors to generate knockout (KO), conditional KO, and subtle mutant alleles
Analysis of genetically engineered mice is crucial for our understanding of the in vivo function of ...
The International Mouse Phenotyping Consortium reports the generation of new mouse mutant strains fo...
Three major mouse knockout programs are underway worldwide, working together to mutate all protein-e...
This unit provides an overview of the major types of mutant alleles that can be generated by gene ta...
Gene targeting in mice has been used extensively to elucidate gene function in vivo. However, for ge...
Conditional gene targeting allows spatial and temporal control of genetic modifications and is used ...
Recent advances in high-throughput gene targeting and conditional mutagenesis are creating new and p...
The critical step in generating a knockout mouse is gene-targeting vector construction. Recombineeri...
Gene targeting in ES cells is extensively used to generate designed mouse mutants and to study gene ...
Gene targeting in ES cells is extensively used to generate designed mouse mutants and to study gene ...
nal gene targeting is an emerging technique for introducing mutations into the genes of laboratory m...
SummaryThe type II bacterial CRISPR/Cas system is a novel genome-engineering technology with the eas...
A type of retroviral gene trap vectors has been developed that can induce conditional mutations in m...
<p>(A) Gene targeting strategy and restriction map of TANK1 gene. Filled boxes indicate exons; label...
The analysis of mutant organisms and cell lines is important in determining the function of specific...
Analysis of genetically engineered mice is crucial for our understanding of the in vivo function of ...
The International Mouse Phenotyping Consortium reports the generation of new mouse mutant strains fo...
Three major mouse knockout programs are underway worldwide, working together to mutate all protein-e...
This unit provides an overview of the major types of mutant alleles that can be generated by gene ta...
Gene targeting in mice has been used extensively to elucidate gene function in vivo. However, for ge...
Conditional gene targeting allows spatial and temporal control of genetic modifications and is used ...
Recent advances in high-throughput gene targeting and conditional mutagenesis are creating new and p...
The critical step in generating a knockout mouse is gene-targeting vector construction. Recombineeri...
Gene targeting in ES cells is extensively used to generate designed mouse mutants and to study gene ...
Gene targeting in ES cells is extensively used to generate designed mouse mutants and to study gene ...
nal gene targeting is an emerging technique for introducing mutations into the genes of laboratory m...
SummaryThe type II bacterial CRISPR/Cas system is a novel genome-engineering technology with the eas...
A type of retroviral gene trap vectors has been developed that can induce conditional mutations in m...
<p>(A) Gene targeting strategy and restriction map of TANK1 gene. Filled boxes indicate exons; label...
The analysis of mutant organisms and cell lines is important in determining the function of specific...
Analysis of genetically engineered mice is crucial for our understanding of the in vivo function of ...
The International Mouse Phenotyping Consortium reports the generation of new mouse mutant strains fo...
Three major mouse knockout programs are underway worldwide, working together to mutate all protein-e...
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