Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: Two genome-wide association studies.
- Reilly, M.P.
- Li, M.
- He, J.
- Ferguson, J.F.
- Stylianou, I.M.
- Mehta, NN.
- Burnett, M.S.
- Devaney, J.M.
- Knouff, C.W.
- Thompson, J.R.
- Horne, B.D.
- Stewart, A.F.
- Assimes, T.L.
- Wild, P.S.
- Allayee, H.
- Nitschke, P.L.
- Patel, RS
- Myocardial Infarction Genetics Consortium ()
- Wellcome Trust Case Control Consortium. ()
- Martinelli, N.
- Girelli, D.
- Quyyumi, A.A.
- Anderson, J.L.
- Erdmann, J.
- Hall, A.S.
- Schunkert, H.
- Quertermous, T.
- Blankenberg, S.
- Hazen, S.L.
- Roberts, R.
- Kathiresan, S.
- Peters, A.
- Wichmann, H.-E.
- Samani, N.J.
- Epstein, S.E.
- Rader, D.J.
DOIAbstract
BACKGROUND: We tested whether genetic factors distinctly contribute to either development of coronary atherosclerosis or, specifically, to myocardial infarction in existing coronary atherosclerosis. METHODS: We did two genome-wide association studies (GWAS) with coronary angiographic phenotyping in participants of European ancestry. To identify loci that predispose to angiographic coronary artery disease (CAD), we compared individuals who had this disorder (n=12,393) with those who did not (controls, n=7383). To identify loci that predispose to myocardial infarction, we compared patients who had angiographic CAD and myocardial infarction (n=5783) with those who had angiographic CAD but no myocardial infarction (n=3644).FINDINGS: In the comp...
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