BACKGROUND: The mechanisms of action of many environmental agents commonly involve oxidative stress resulting from mitochondrial dysfunction. Zinc is a common environmental metallic contaminant that has been implicated in a variety of oxidant-dependent toxicological responses. Unlike ions of other transition metals such as iron, copper, and vanadium, Zn(2+) does not generate reactive oxygen species (ROS) through redox cycling. OBJECTIVE: To characterize the role of oxidative stress in zinc-induced toxicity. METHODS: We used an integrated imaging approach that employs the hydrogen peroxide (H2O2)-specific fluorophore Peroxy Green 1 (PG1), the mitochondrial potential sensor 5,5 ,6,6 -tetrachloro-1,1 ,3,3 -tetraethylbenzimidazolylcarbocyanine ...
Our aim was to determine if NO prevents mitochondrial oxidant damage by mobilizing intracellular fre...
Chelatable, mobile forms of divalent zinc, Zn(II), play essential signaling roles in mammalian biolo...
Our aim was to determine if NO prevents mitochondrial oxidant damage by mobilizing intracellular fre...
BackgroundThe mechanisms of action of many environmental agents commonly involve oxidative stress re...
BackgroundThe mechanisms of action of many environmental agents commonly involve oxidative stress re...
BackgroundThe mechanisms of action of many environmental agents commonly involve oxidative stress re...
International audienceIncreased production and use of zinc oxide nanoparticles (ZnO-NPs) in consumer...
International audienceIncreased production and use of zinc oxide nanoparticles (ZnO-NPs) in consumer...
Zinc is a ubiquitous heavy metal that binds to proteins involved in critical cellular processes. Apa...
International audienceIncreased production and use of zinc oxide nanoparticles (ZnO-NPs) in consumer...
International audienceIncreased production and use of zinc oxide nanoparticles (ZnO-NPs) in consumer...
Zinc is a highly abundant cation in the brain, essential for cellular functions, including transcrip...
The zinc ion (Zn2+) is emerging as an important signaling molecule. Here, we engineered an improved ...
The zinc ion is an important emerging signaling molecule for biological processes. In this work we e...
Zinc is a micronutrient that is required for cellular growth, proliferation, and differentiation. Do...
Our aim was to determine if NO prevents mitochondrial oxidant damage by mobilizing intracellular fre...
Chelatable, mobile forms of divalent zinc, Zn(II), play essential signaling roles in mammalian biolo...
Our aim was to determine if NO prevents mitochondrial oxidant damage by mobilizing intracellular fre...
BackgroundThe mechanisms of action of many environmental agents commonly involve oxidative stress re...
BackgroundThe mechanisms of action of many environmental agents commonly involve oxidative stress re...
BackgroundThe mechanisms of action of many environmental agents commonly involve oxidative stress re...
International audienceIncreased production and use of zinc oxide nanoparticles (ZnO-NPs) in consumer...
International audienceIncreased production and use of zinc oxide nanoparticles (ZnO-NPs) in consumer...
Zinc is a ubiquitous heavy metal that binds to proteins involved in critical cellular processes. Apa...
International audienceIncreased production and use of zinc oxide nanoparticles (ZnO-NPs) in consumer...
International audienceIncreased production and use of zinc oxide nanoparticles (ZnO-NPs) in consumer...
Zinc is a highly abundant cation in the brain, essential for cellular functions, including transcrip...
The zinc ion (Zn2+) is emerging as an important signaling molecule. Here, we engineered an improved ...
The zinc ion is an important emerging signaling molecule for biological processes. In this work we e...
Zinc is a micronutrient that is required for cellular growth, proliferation, and differentiation. Do...
Our aim was to determine if NO prevents mitochondrial oxidant damage by mobilizing intracellular fre...
Chelatable, mobile forms of divalent zinc, Zn(II), play essential signaling roles in mammalian biolo...
Our aim was to determine if NO prevents mitochondrial oxidant damage by mobilizing intracellular fre...