Early exposure to microbes reduces the risk for asthma. Toll-like receptors (TLRs) represent a major group of receptors for the specific recognition of pathogen-associated molecular patterns of microbes capable of activating innate and adaptive immunity. OBJECTIVE: Because TLRs can influence key events in the induction and perpetuation of asthma and atopy, we sought to determine whether genetic alterations in TLR genes affect asthma risk. METHODS: We systematically evaluated putatively functional genetic variants in all 10 human TLR genes for their association with different asthma phenotypes in a case-control study (n = 1872) by using matrix-assisted laser desorption/ionization time-of-flight genotyping. For polymorphisms showing associati...
P>Background:The toll-like receptor (TLR)-related pathway is important in host defence and may be...
P>Background:The toll-like receptor (TLR)-related pathway is important in host defence and may be...
P>Background:The toll-like receptor (TLR)-related pathway is important in host defence and may be...
Toll-like receptors (TLRs 1-10) represent a major group of receptors for the specific recognition of...
Endotoxin exposure may have a protective effect against asthma and atopy. An Asp299Gly polymorphism ...
Background: The toll-like receptor (TLR)-related pathway is important in host defence and may be cru...
Background: The toll-like receptor (TLR)-related pathway is important in host defence and may be cru...
Background: The toll-like receptor (TLR)-related pathway is important in host defence and may be cru...
Background: The toll-like receptor (TLR)-related pathway is important in host defence and may be cru...
BACKGROUND: The toll-like receptor (TLR)-related pathway is important in host defence and may be cru...
Background: The toll-like receptor (TLR)-related pathway is important in host defence and may be cru...
Endotoxin exposure may have a protective effect against asthma and atopy. An Asp299Gly polymorphism ...
BACKGROUND: The toll-like receptor (TLR)-related pathway is important in host defence and may be cru...
P>Background: The toll-like receptor (TLR)-related pathway is important in host defence and may be c...
P>Background:The toll-like receptor (TLR)-related pathway is important in host defence and may be...
P>Background:The toll-like receptor (TLR)-related pathway is important in host defence and may be...
P>Background:The toll-like receptor (TLR)-related pathway is important in host defence and may be...
P>Background:The toll-like receptor (TLR)-related pathway is important in host defence and may be...
Toll-like receptors (TLRs 1-10) represent a major group of receptors for the specific recognition of...
Endotoxin exposure may have a protective effect against asthma and atopy. An Asp299Gly polymorphism ...
Background: The toll-like receptor (TLR)-related pathway is important in host defence and may be cru...
Background: The toll-like receptor (TLR)-related pathway is important in host defence and may be cru...
Background: The toll-like receptor (TLR)-related pathway is important in host defence and may be cru...
Background: The toll-like receptor (TLR)-related pathway is important in host defence and may be cru...
BACKGROUND: The toll-like receptor (TLR)-related pathway is important in host defence and may be cru...
Background: The toll-like receptor (TLR)-related pathway is important in host defence and may be cru...
Endotoxin exposure may have a protective effect against asthma and atopy. An Asp299Gly polymorphism ...
BACKGROUND: The toll-like receptor (TLR)-related pathway is important in host defence and may be cru...
P>Background: The toll-like receptor (TLR)-related pathway is important in host defence and may be c...
P>Background:The toll-like receptor (TLR)-related pathway is important in host defence and may be...
P>Background:The toll-like receptor (TLR)-related pathway is important in host defence and may be...
P>Background:The toll-like receptor (TLR)-related pathway is important in host defence and may be...
P>Background:The toll-like receptor (TLR)-related pathway is important in host defence and may be...