Two new loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and German study groups.
- Scherag, A.
- Dina, C.
- Hinney, A.
- Vatin, V.
- Scherag, S.
- Vogel, C.I.G.
- Müller, T.D.
- Grallert, H.
- Wichmann, H.-E.
- Balkau, B.
- Heude, B.
- Jarvelin, M.R.
- Hartikainen, A.L.
- Lévy-Marchal, C.
- Weill, J.
- Delplanque, J.
- Körner, A.
- Kiess, W.
- Kovacs, P.
- Rayner, N.W.
- Prokopenko, I.
- McCarthy, M.I.
- Schäfer, H.
- Jarick, I.
- Boeing, H.
- Fisher, E.
- Reinehr, T.
- Heinrich, J.
- Rzehak, P.
- Berdel, D.
- Borte, M.
- Biebermann, H.
- Krude, H.
- Rosskopf, D.
- Rimmbach, C.
- Rief, W.
- Fromme, T.
- Klingenspor, M.
- Schürmann, A.
- Schulz, N.
- Nöthen, M.M.
- Mühleisen, T.W.
- Erbel, R.
- Jöckel, K.-H.
- Moebus, S.
- Boes, T.
- Illig, T.
- Froguel, P.
- Hebebrand, J.
- Meyre, D.
DOIAbstract
Meta-analyses of population-based genome-wide association studies (GWAS) in adults have recently led to the detection of new genetic loci for obesity. Here we aimed to discover additional obesity loci in extremely obese children and adolescents. We also investigated if these results generalize by estimating the effects of these obesity loci in adults and in population-based samples including both children and adults. We jointly analysed two GWAS of 2,258 individuals and followed-up the best, according to lowest p-values, 44 single nucleotide polymorphisms (SNP) from 21 genomic regions in 3,141 individuals. After this DISCOVERY step, we explored if the findings derived from the extremely obese children and adolescents (10 SNPs from 5 genomic...
Add to ORKG