Genome-wide association study reveals genetic risk underlying Parkinson's disease.
- Simon-Sanchez, J.
- Schulte, C.
- Bras, J.M.
- Sharma, M.
- Gibbs, J.R.
- Berg, D.
- Paisan-Ruiz, C.
- Lichtner, P.
- Scholz, S.W.
- Hernandez, D.G.
- Kruger, R.
- Federoff, M.
- Klein, C.
- Goate, A.
- Perlmutter, J.
- Bonin, M.
- Nalls, M.A.
- Illig, T.
- Gieger, C.
- Houlden, H.
- Steffens, M.
- Okun, M.S.
- Racette, B.A.
- Cookson, M.R.
- Foote, K.D.
- Fernandez, H.H.
- Traynor, B.J.
- Schreiber, S.
- Arepalli, S.
- Zonozi, R.
- Gwinn, K.
- van der Brug, M.
- Lopez, G.
- Chanock, S.J.
- Schatzkin, A.
- Park, Y.
- Hollenbeck, A.
- Gao, J.J.
- Huang, X.M.
- Wood, N.W.
- Lorenz, D.
- Deuschl, G.
- Chen, H.L.
- Riess, O.
- Hardy, J.A.
- Singleton, A.B.
- Gasser, T.
DOIAbstract
We performed a genome-wide association study (GWAS) in 1,713 individuals of European ancestry with Parkinson's disease (PD) and 3,978 controls. After replication in 3,361 cases and 4,573 controls, we observed two strong association signals, one in the gene encoding a-synuclein (SNCA; rs2736990, OR = 1.23, P = 2.24 x 10(-16)) and another at the MAPT locus (rs393152, OR = 0.77, P = 1.95 x 10(-16)). We exchanged data with colleagues performing a GWAS in Japanese PD cases. Association to PD at SNCA was replicated in the Japanese GWAS1, confirming this as a major risk locus across populations. We replicated the effect of a new locus detected in the Japanese cohort (PARK16, rs823128, OR = 0.66, P = 7.29 x 10(-8)) and provide supporting eviden...
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