Despite being exposed to microbial and food antigens, the human gastrointestinal tract does not exist in a state of inflammation. This homeostasis is critically dependent on the colonic epithelial barrier, which when dysfunctional is associated with inflammatory bowel disease (IBD), obesity and type two diabetes. Limitations in current models of the colonic epithelial barrier have driven the development of human colonic organoids, organotypic 3D models of the colonic epithelium derived from colonic stem cells. While colonic organoids are an exciting new model, they contain only 2-5% goblet cells, a critical secretory component of the barrier, in contrast to the ~50% expression seen in native colonic tissue. High Wnt and Notch signalling ...
Many systems biology studies lack context-relevant data and as a consequence the predictive capabili...
The limitations of existing cell culture and animal studies have provided an impetus for the develop...
Abstract Stem cell driven tissue renewal in the intestinal epithelium is a tightly regulated and co...
The intestine is home to a large number of commensal microbes, which are restricted to the intestina...
The colonic epithelium facilitates host-microorganism interactions to control mucosal immunity, coor...
It’s unknown if the increased intestinal permeability in patients with Crohn’s Disease (CD) is a cau...
The polarity of proliferative and differentiated cellular compartments of colonic crypts is believed...
<div><p>Although small intestinal epithelial stem cells form crypts when using intestinal culture co...
Three-dimensional primary cultures of colonic epithelium, or colonic organoids, are thought to be a ...
Background The human intestinal epithelium is one of the most rapidly renewing tissues in the mammal...
AbstractThe small intestine consists of two histological compartments composed of the crypts and the...
Inflammatory bowel disease (IBD) is a collective term for inflammatory conditions that affect the ga...
The polarity of proliferative and differentiated cellular compartments of colonic crypts is believed...
Although small intestinal epithelial stem cells form crypts when using intestinal culture conditions...
Intestinal epithelial cell polarity and lineages along the crypt-villus axis provide an excellent mo...
Many systems biology studies lack context-relevant data and as a consequence the predictive capabili...
The limitations of existing cell culture and animal studies have provided an impetus for the develop...
Abstract Stem cell driven tissue renewal in the intestinal epithelium is a tightly regulated and co...
The intestine is home to a large number of commensal microbes, which are restricted to the intestina...
The colonic epithelium facilitates host-microorganism interactions to control mucosal immunity, coor...
It’s unknown if the increased intestinal permeability in patients with Crohn’s Disease (CD) is a cau...
The polarity of proliferative and differentiated cellular compartments of colonic crypts is believed...
<div><p>Although small intestinal epithelial stem cells form crypts when using intestinal culture co...
Three-dimensional primary cultures of colonic epithelium, or colonic organoids, are thought to be a ...
Background The human intestinal epithelium is one of the most rapidly renewing tissues in the mammal...
AbstractThe small intestine consists of two histological compartments composed of the crypts and the...
Inflammatory bowel disease (IBD) is a collective term for inflammatory conditions that affect the ga...
The polarity of proliferative and differentiated cellular compartments of colonic crypts is believed...
Although small intestinal epithelial stem cells form crypts when using intestinal culture conditions...
Intestinal epithelial cell polarity and lineages along the crypt-villus axis provide an excellent mo...
Many systems biology studies lack context-relevant data and as a consequence the predictive capabili...
The limitations of existing cell culture and animal studies have provided an impetus for the develop...
Abstract Stem cell driven tissue renewal in the intestinal epithelium is a tightly regulated and co...