Synthesis of \u3cem\u3ecis\u3c/em\u3e-[Cr(diimine)\u3csub\u3e2\u3c/sub\u3e(1-methylimidazole)\u3csub\u3e2\u3c/sub\u3e]\u3csup\u3e3+\u3c/sup\u3e Complexes and an Investigation of Their Interaction with Mononucleotides and Polynucleotides
- Goforth, Sarah K
- Gill, Thomas W
- Weisbruch, April E
- Kane-Maguire, Kimberlee A
- Helsel, Marian E
- Sun, Katherine W
- Rodgers, Hillary D
- Stanley, Floyd E
- Goudy, Samuel R
- Wheeler, Sandra K.
- Wheeler, John F
- Kane-Maguire, Noel A P
Publication date
February 2016
DOI Publisher
American Chemical Society (ACS)Abstract
A protocol is presented for the synthesis of chromium(III) complexes of the type cis-[Cr(diimine)2(1-methylimidazole)2]3+. These compounds exhibit large excited- state oxidizing powers and strong luminescence in solution.Emission is quenched by added guanine, yielding rate constants that track the driving force for guanine oxidation. The cis-[Cr(TMP)(DPPZ)(1-MeImid)2]3+species binds strongly to duplex DNA with a preference for AT base sites in the minor groove and may serve as a precursor for photo activated DNA covalent adduct formation
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