Directed cell migration is central to embryonic development, tissue homeostasis, and disease progression. However, regulation of cell migration is notoriously difficult to study. Although past experiments have shown purified extracellular matrix (ECM) proteins can direct cell migration, whether multiple ECMs can guide cell migration remains unknown. Here, I simultaneously pattern multiple ECMs via a simple extension of microcontact printing. Through this method, I find a continuous cell-ECM adhesion can be composed of distinct types of integrins segregated to different ECMs, and that cells can migrate directionally on an ensemble of ECMs just as well as they can on single ECMs. Together, these data directly suggest that integrins coordinate...
Cell migration is a fundamental element in a variety of physiological and pathological processes. Al...
Cell migration is central to a multitude of physiological processes, including embryonic development...
Cell migration is a crucial event for tissue organization during development, and its dysregulation ...
Directed cell migration is central to embryonic development, tissue homeostasis, and disease progres...
Cell adhesion to the substratum and/or other cells is a crucial step of cell migration. While essent...
Dynamic regulation of cell adhesion on extracellular matrix (ECM) proteins plays vital roles in the ...
The ability of cells to migrate is a fundamental physiological process involved in embryonic develop...
International audienceChemical and physical properties of the environment control cell proliferation...
Cell-matrix adhesion complexes (CMACs) are foci of cellular attachment to the extracellular matrix (...
International audienceChemical and physical properties of the environment control cell proliferation...
Collective cell migration is required in a vast array of biological phenomena, including organogenes...
Collective cell migration is required in a vast array of biological phenomena, including organogenes...
Introduction: Understanding how extracellular matrix (ECM) protein composition regulates the process...
Physical features of the extracellular matrix (ECM) heavily influence cell migration strategies and ...
Physical features of the extracellular matrix (ECM) heavily influence cell migration strategies and ...
Cell migration is a fundamental element in a variety of physiological and pathological processes. Al...
Cell migration is central to a multitude of physiological processes, including embryonic development...
Cell migration is a crucial event for tissue organization during development, and its dysregulation ...
Directed cell migration is central to embryonic development, tissue homeostasis, and disease progres...
Cell adhesion to the substratum and/or other cells is a crucial step of cell migration. While essent...
Dynamic regulation of cell adhesion on extracellular matrix (ECM) proteins plays vital roles in the ...
The ability of cells to migrate is a fundamental physiological process involved in embryonic develop...
International audienceChemical and physical properties of the environment control cell proliferation...
Cell-matrix adhesion complexes (CMACs) are foci of cellular attachment to the extracellular matrix (...
International audienceChemical and physical properties of the environment control cell proliferation...
Collective cell migration is required in a vast array of biological phenomena, including organogenes...
Collective cell migration is required in a vast array of biological phenomena, including organogenes...
Introduction: Understanding how extracellular matrix (ECM) protein composition regulates the process...
Physical features of the extracellular matrix (ECM) heavily influence cell migration strategies and ...
Physical features of the extracellular matrix (ECM) heavily influence cell migration strategies and ...
Cell migration is a fundamental element in a variety of physiological and pathological processes. Al...
Cell migration is central to a multitude of physiological processes, including embryonic development...
Cell migration is a crucial event for tissue organization during development, and its dysregulation ...