Proteins exhibit a wide range of physical and chemical properties, including highly selective molecular recognition and catalysis, and are also key components in biological metabolic, catabolic, and signaling pathways. Given that proteins are well-structured and can now be rapidly synthesized, they are excellent targets for engineering of both molecular structure and biological function. Computational analysis of the protein design problem allows scientists to explore sequence space and systematically discover novel protein molecules. Nonetheless, the complexity of proteins, the subtlety of the determinants of folding, and the exponentially large number of possible sequences impede the search for peptide sequences compatible with a desired ...
The first fully automated design and experimental validation of a novel sequence for an entire prote...
Computational protein design aims to predict protein sequences that will fold into a given three-dim...
Rational and computational protein design have been studied extensively during the past two decades....
Proteins exhibit a wide range of physical and chemical properties, including highly selective molecu...
Computational protein design method has been developed to understand the underling physicochemical p...
Protein design critically tests our understanding of principles that specify the protein folded stat...
Protein design critically tests our understanding of principles that specify the protein folded stat...
Computational protein design facilitates the continued development of methods for the design of biom...
Computational and theoretical methods are advancing protein design as a means to create and investig...
The stability, activity, and solubility of a protein sequence are determined by a delicate balance o...
Combinatorial experiments provide new ways to probe the determinants of protein folding and to ident...
Advances in nanotechnology have the potential to utilize biological and polymeric systems to address...
AbstractProteins are the most multifaceted macromolecules in living systems and have various importa...
AbstractA ‘protein design cycle’, involving cycling between theory and experiment, has led to recent...
Advances in nanotechnology have the potential to utilize biological and polymeric systems to address...
The first fully automated design and experimental validation of a novel sequence for an entire prote...
Computational protein design aims to predict protein sequences that will fold into a given three-dim...
Rational and computational protein design have been studied extensively during the past two decades....
Proteins exhibit a wide range of physical and chemical properties, including highly selective molecu...
Computational protein design method has been developed to understand the underling physicochemical p...
Protein design critically tests our understanding of principles that specify the protein folded stat...
Protein design critically tests our understanding of principles that specify the protein folded stat...
Computational protein design facilitates the continued development of methods for the design of biom...
Computational and theoretical methods are advancing protein design as a means to create and investig...
The stability, activity, and solubility of a protein sequence are determined by a delicate balance o...
Combinatorial experiments provide new ways to probe the determinants of protein folding and to ident...
Advances in nanotechnology have the potential to utilize biological and polymeric systems to address...
AbstractProteins are the most multifaceted macromolecules in living systems and have various importa...
AbstractA ‘protein design cycle’, involving cycling between theory and experiment, has led to recent...
Advances in nanotechnology have the potential to utilize biological and polymeric systems to address...
The first fully automated design and experimental validation of a novel sequence for an entire prote...
Computational protein design aims to predict protein sequences that will fold into a given three-dim...
Rational and computational protein design have been studied extensively during the past two decades....