A High Power Target for the Production of 18F Fluoride

A target for high yield production of aqueous [18F] fluoride at high beam currents has been developed for the 11 MeV Siemens/CTI RDS proton cyclotron at the University of Wisconsin. The silver body, gold backed target is characterized a small volume (400 μl) and is operated at high pressure (40 bar). The target yield is 79% of the theoretical maximum for beam currents up to 40 μA. The highest yield to date is 70 GBq. Target construction and performance are presented, and recent applications to PET radioisotope syntheses and radioactive beam production are discussed