This thesis is a comparison of the smooth and topological categories in dimension 4. We first discuss lists of homeomorphic 4-manifolds with non-equivalent “exotic” smooth structures, and show that any finite list of smooth, closed, simply-connected 4-manifolds that are homeomorphic to a given one X can be obtained by removing a single compact contractible submanifold (or cork) from X, and then regluing it by powers of a boundary diffeomorphism. Furthermore, by allowing the cork to be noncompact, the collection of all the smooth manifolds homeomorphic to X can be obtained in this way. The existence of a universal noncompact cork is also established. The results in the second half of the thesis illustrate the difference between the smooth is...