The Mediterranean Sea is one of the biggest reservoirs of biodiversity in the world. Millions of people directly or indirectly depend on the ecosystem services it provides, in particular the provisioning of fisheries resources. Rather than a hot-spot of biodiversity, the Mediterranean Sea has now become a hot-spot of global change where climate change and other anthropogenic pressures (e.g., overfishing, pollution, habitat destruction) operate independently or synergistically to shape an altered Mediterranean Sea that may shift from the today picture. The set of physical-chemical changes triggered by climate change may disrupt the functioning of the biological components of ecosystems, from the individual up to the ecosystem scale, from the...