Synthesis of Chiral Fluorinated Propargylamines via Chemoselective Biomimetic Hydrogenation

A highly enantioselective synthesis of chiral fluorinated propargylamines was developed through phosphoric acid and ruthenium-catalyzed chemoselective biomimetic hydrogenation of the carbon nitrogen double bond of fluorinated alkynyl ketimines in the presence of a carbon carbon triple bond. This reaction features high chemoselectivity and slow background reaction. In addition, selective transformations of the chiral fluorinated propargylamines were also reported